Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person During HHV8 lytic replication, the viral ORF57 protein engag...
| Class:Id | Summation:9991429 |
|---|---|
| _displayName | During HHV8 lytic replication, the viral ORF57 protein engag... |
| _timestamp | 2026-06-04 17:30:48 |
| created | [InstanceEdit:9991336] Stephan, Ralf, 2026-06-04 |
| text | During HHV8 lytic replication, the viral ORF57 protein engages the cap-binding complex (CBC) on intronless viral transcripts by binding directly to NCBP1, the large subunit of the heterodimeric CBC bound at the 5' m7G cap of RNA polymerase II transcripts (Cheng et al. 2006). GST pull-down assays with in vitro-translated NCBP1 demonstrated a direct ORF57-NCBP1 interaction, and co-immunoprecipitations from reactivated BCBL-1 cells confirmed that endogenous ORF57 associates with NCBP1 during viral lytic infection (Boyne et al. 2008); this interaction is RNA-independent (Ruiz et al. 2019). Through this contact, ORF57 is tethered near the 5' end of viral mRNA in complex with CBC, providing a platform for subsequent recruitment of the hTREX export machinery to intronless HHV8 transcripts (Boyne et al. 2008). |
| (summation) | [Reaction:9991370] ORF57:mRNA binds NCBP1,NCBP2 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by During HHV8 lytic replication, the viral ORF57 protein engag... (9991429)
