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Details on Person ORF57 recruits ALYREF to mRNA

Class:Id	Reaction:9991406
_displayName	ORF57 recruits ALYREF to mRNA
_doRelease	FALSE
_timestamp	2026-06-04 17:50:37
authored	[InstanceEdit:9991285] Stephan, Ralf, 2026-05-26
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9991336] Stephan, Ralf, 2026-06-04
disease	[Disease:3134794] viral infectious disease
input	[Complex:9991317] ORF57:mRNA:CBC [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:156649] ALYREF [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9991360] Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication [LiteratureReference:9991350] The evolutionarily conserved Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with REF protein and acts as an RNA export factor [LiteratureReference:9991383] Binding of cellular export factor REF/Aly by Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is not required for efficient KSHV lytic replication [LiteratureReference:9991397] Kaposi's sarcoma-associated herpesvirus ORF57 is not a bona fide export factor [LiteratureReference:9991367] Viral factors reveal a role for REF/Aly in nuclear RNA stability [LiteratureReference:9991327] An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export
name	ORF57 recruits ALYREF to mRNA
output	[Complex:9991359] ORF57:mRNA:CBC:ALYREF [nucleoplasm] [Homo sapiens]
relatedSpecies	[Species:2671781] Human herpesvirus 8
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9991449] R-HSA-9991406.1
summation	[Summation:9991376] HHV8 ORF57 directly binds the cellular export adaptor ALYREF...
(hasEvent)	[Pathway:9991330] Export of HHV8 transcripts from nucleus [Homo sapiens]
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No pathways have been reviewed or authored by ORF57 recruits ALYREF to mRNA (9991406)