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Details on Person ORF57:mRNA binds NCBP1,NCBP2

Class:IdReaction:9991370
_displayNameORF57:mRNA binds NCBP1,NCBP2
_doReleaseFALSE
_timestamp2026-06-04 17:50:39
authored[InstanceEdit:9991285] Stephan, Ralf, 2026-05-26
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9991336] Stephan, Ralf, 2026-06-04
disease[Disease:3134794] viral infectious disease
input[Complex:9991298] ORF57:mRNA [nucleoplasm] [Human herpesvirus 8]
[EntityWithAccessionedSequence:51469] NCBP1 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:51463] NCBP2 [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:8850604] Human mRNA export machinery recruited to the 5' end of mRNA
[LiteratureReference:9991360] Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication
[LiteratureReference:9991390] Kaposi's sarcoma-associated herpesvirus ORF57 protein protects viral transcripts from specific nuclear RNA decay pathways by preventing hMTR4 recruitment
[LiteratureReference:9991316] Interplay between polyadenylate-binding protein 1 and Kaposi's sarcoma-associated herpesvirus ORF57 in accumulation of polyadenylated nuclear RNA, a viral long noncoding RNA
nameORF57:mRNA binds NCBP1,NCBP2
output[Complex:9991317] ORF57:mRNA:CBC [nucleoplasm] [Homo sapiens]
relatedSpecies[Species:2671781] Human herpesvirus 8
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9991477] R-HSA-9991370.1
summation[Summation:9991429] During HHV8 lytic replication, the viral ORF57 protein engag...
(hasEvent)[Pathway:9991330] Export of HHV8 transcripts from nucleus [Homo sapiens]
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No pathways have been reviewed or authored by ORF57:mRNA binds NCBP1,NCBP2 (9991370)
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