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Details on Person At the nuclear pore, NXF1 (TAP) bound to NXT1 (p15) receives...
| Class:Id | Summation:9991368 |
|---|---|
| _displayName | At the nuclear pore, NXF1 (TAP) bound to NXT1 (p15) receives... |
| _timestamp | 2026-06-04 17:29:26 |
| created | [InstanceEdit:9991336] Stephan, Ralf, 2026-06-04 |
| text | At the nuclear pore, NXF1 (TAP) bound to NXT1 (p15) receives the viral mRNA from the TREX adaptor ALYREF through a mutually exclusive handover: NXF1 binding to ALYREF displaces RNA from ALYREF because the ALYREF N-terminal arginine-rich peptide (residues 16–36, with R29/R30 critical) overlaps the ALYREF RNA-binding surface, while RNA cross-linking to NXF1 via its arginine-rich N-terminal RBD is concomitantly enhanced ~4-fold, as shown by in vitro UV-cross-linking, EMSA, GST-pulldown reconstitutions and in vivo NXF1-overexpression competition assays (Hautbergue et al. 2008). NXF1:NXT1 then engages nucleoporin FG repeats to translocate the mRNA to the cytoplasm, whiIe ALYREF and the rest of TREX are released back into the nucleoplasm (Hautbergue et al. 2008). |
| (summation) | [BlackBoxEvent:9991382] Translocation of HHV8 mRNA through nuclear pore complex [Homo sapiens] |
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No pathways have been reviewed or authored by At the nuclear pore, NXF1 (TAP) bound to NXT1 (p15) receives... (9991368)
