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Details on Person HHV8 ORF57, a multifunctional nuclear post-transcriptional r...
| Class:Id | Summation:9991325 |
|---|---|
| _displayName | HHV8 ORF57, a multifunctional nuclear post-transcriptional r... |
| _timestamp | 2026-06-04 17:28:36 |
| created | [InstanceEdit:9991336] Stephan, Ralf, 2026-06-04 |
| text | HHV8 ORF57, a multifunctional nuclear post-transcriptional regulator of viral lytic gene expression, associates directly with intronless viral transcripts such as ORF59 mRNA, as demonstrated by UV cross-linking and immunoprecipitation of ORF57-RNA complexes from butyrate-induced HHV8-positive JSC-1 cells and by in vitro binding of recombinant FLAG-tagged ORF57 to radiolabelled ORF59 RNA, with little binding to control luciferase RNA (Majerciak et al. 2006). The interaction depends on the basic N-terminal NLS motifs of ORF57 and is greatly enhanced by nuclear extract, indicating that ORF57 contacts target mRNAs in the nucleoplasm (Majerciak et al. 2006). Other abundant intronless HHV8 lytic transcripts, including the non-coding polyadenylated nuclear (PAN) RNA, are similarly produced and retained in the nucleus during lytic replication, providing the substrate pool for ORF57-mediated post-transcriptional regulation (Conrad and Steitz 2005; Conrad et al. 2006). |
| (summation) | [Reaction:9991377] ORF57 binds HHV8 mRNA [Homo sapiens] |
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