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Details on Person DDX39B recruits THO complex

Class:Id	BlackBoxEvent:9991321
_displayName	DDX39B recruits THO complex
_doRelease	FALSE
_timestamp	2026-06-04 17:50:44
authored	[InstanceEdit:9991319] Stephan, Ralf, 2026-05-27
catalystActivity	[CatalystActivity:9991421] ATP-dependent protein binding activity of ORF57:mRNA:CBC:ALYREF:DDX39B(ATP) [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9991336] Stephan, Ralf, 2026-06-04
disease	[Disease:3134794] viral infectious disease
input	[Complex:9991363] ORF57:mRNA:CBC:ALYREF:DDX39B(ATP) [nucleoplasm] [Homo sapiens] [Complex:8849128] THO complex [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9991360] Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication [LiteratureReference:9991327] An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export [LiteratureReference:9991288] Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly [LiteratureReference:9991306] Targeting the ATP-dependent formation of herpesvirus ribonucleoprotein particle assembly as an antiviral approach [LiteratureReference:9991427] Requirement of UAP56, URH49, RBM15, and OTT3 in the expression of Kaposi sarcoma-associated herpesvirus ORF57
name	DDX39B recruits THO complex
output	[Complex:9991281] ORF57:mRNA:TREX complex [nucleoplasm] [Homo sapiens] [SimpleEntity:113550] Pi [nucleoplasm]
relatedSpecies	[Species:2671781] Human herpesvirus 8
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9991439] R-HSA-9991321.1
summation	[Summation:9991351] On the HHV8 intronless viral mRNA, DDX39B — already tethered...
(hasEvent)	[Pathway:9991330] Export of HHV8 transcripts from nucleus [Homo sapiens]
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No pathways have been reviewed or authored by DDX39B recruits THO complex (9991321)