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Details on Person ORF56 synthesizes RNA primers

Class:IdBlackBoxEvent:9991230
_displayNameORF56 synthesizes RNA primers
_doReleaseFALSE
_timestamp2026-06-04 16:48:17
authored[InstanceEdit:9991238] Stephan, Ralf, 2026-05-18
catalystActivity[CatalystActivity:9991226] DNA-directed RNA polymerase activity of Episome:Replication Initiation Complex:ssDNA:DBP [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9991213] Stephan, Ralf, 2026-06-04
disease[Disease:3134794] viral infectious disease
input[Complex:9991222] Episome:Replication Initiation Complex:ssDNA:DBP [nucleoplasm] [Homo sapiens]
[SimpleEntity:9757634] NTP [nucleoplasm]
[SimpleEntity:9757634] NTP [nucleoplasm]
[SimpleEntity:9757634] NTP [nucleoplasm]
[SimpleEntity:9757634] NTP [nucleoplasm]
[SimpleEntity:9757634] NTP [nucleoplasm]
[SimpleEntity:9757634] NTP [nucleoplasm]
[SimpleEntity:9757634] NTP [nucleoplasm]
[SimpleEntity:9757634] NTP [nucleoplasm]
[SimpleEntity:9757634] NTP [nucleoplasm]
[SimpleEntity:9757634] NTP [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:9982102] Amplification of the Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 lytic origin of DNA replication is dependent upon a cis-acting AT-rich region and an ORF50 response element and the trans-acting factors ORF50 (K-Rta) and K8 (K-bZIP)
[LiteratureReference:9978203] Origin-independent assembly of Kaposi's sarcoma-associated herpesvirus DNA replication compartments in transient cotransfection assays and association with the ORF-K8 protein and cellular PML
nameORF56 synthesizes RNA primers
output[Complex:9991236] Episome:Replication Initiation Complex:ssDNA:DBP:RNA primer [nucleoplasm] [Homo sapiens]
[SimpleEntity:113541] PPi [nucleoplasm]
precedingEvent
relatedSpecies[Species:2671781] Human herpesvirus 8
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9991248] R-HSA-9991230.1
summation[Summation:9991184] Within the HHV8 lytic replication machinery, the ORF56 prima...
(hasEvent)[Pathway:9987685] HHV8 Lytic Genome Replication [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9991180] Primer extension and rolling-circle DNA replication [Homo sapiens]
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No pathways have been reviewed or authored by ORF56 synthesizes RNA primers (9991230)
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