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Details on Person Primer extension and rolling-circle DNA replication

Class:Id	BlackBoxEvent:9991180
_displayName	Primer extension and rolling-circle DNA replication
_doRelease	FALSE
_timestamp	2026-06-04 16:48:17
authored	[InstanceEdit:9991238] Stephan, Ralf, 2026-05-18
catalystActivity	[CatalystActivity:9991216] DNA-directed DNA polymerase activity of Episome:Replication Initiation Complex:ssDNA:DBP:RNA primer [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9991213] Stephan, Ralf, 2026-06-04
crossReference	[DatabaseIdentifier:9991204] RHEA:22509
disease	[Disease:3134794] viral infectious disease
input	[Complex:9991236] Episome:Replication Initiation Complex:ssDNA:DBP:RNA primer [nucleoplasm] [Homo sapiens] [OtherEntity:9991205] n x 275,938 x dNTP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:9982102] Amplification of the Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 lytic origin of DNA replication is dependent upon a cis-acting AT-rich region and an ORF50 response element and the trans-acting factors ORF50 (K-Rta) and K8 (K-bZIP) [LiteratureReference:9979037] Phosphorylation of Kaposi's sarcoma-associated herpesvirus processivity factor ORF59 by a viral kinase modulates its ability to associate with RTA and oriLyt [LiteratureReference:9981385] DNA-Binding Activities of KSHV DNA Polymerase Processivity Factor (PF-8) Complexes [LiteratureReference:9989122] Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus
name	Primer extension and rolling-circle DNA replication
output	[Polymer:9986681] Concatemeric viral dsDNA(n) [nucleoplasm] [Human herpesvirus 8] [OtherEntity:9991178] n x 275,938 x PPi [nucleoplasm] [Complex:9991222] Episome:Replication Initiation Complex:ssDNA:DBP [nucleoplasm] [Homo sapiens] [GenomeEncodedEntity:9991195] RNA primer [nucleoplasm] [Human herpesvirus 8]
precedingEvent	[BlackBoxEvent:9991230] ORF56 synthesizes RNA primers [Homo sapiens] [BlackBoxEvent:9991233] DBP coats unwound ssDNA [Homo sapiens] [BlackBoxEvent:9991180] Primer extension and rolling-circle DNA replication [Homo sapiens]
relatedSpecies	[Species:2671781] Human herpesvirus 8
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9991256] R-HSA-9991180.1
summation	[Summation:9991203] At HHV8 ori-Lyt, the viral DNA polymerase ORF9 catalyses tem...
(hasEvent)	[Pathway:9987685] HHV8 Lytic Genome Replication [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9991230] ORF56 synthesizes RNA primers [Homo sapiens]
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No pathways have been reviewed or authored by Primer extension and rolling-circle DNA replication (9991180)