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Details on Person NLRP1 senses viral dsRNA

Class:Id	Reaction:9988992
_displayName	NLRP1 senses viral dsRNA
_doRelease	FALSE
_timestamp	2026-05-14 01:57:28
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9988942] Shamovsky, Veronica, 2026-05-14
input	[Complex:9988921] DPP9, DPP8:NLRP1:NLRP1(1213-1473) [cytosol] [Homo sapiens] [Complex:9988960] SFV dsRNA intermediates [cytosol] [Semliki Forest virus]
isChimeric	FALSE
literatureReference	[LiteratureReference:9988915] Human NLRP1 is a sensor for double-stranded RNA
name	NLRP1 senses viral dsRNA
output	[Complex:9988933] DPP9, DPP8:NLRP1:NLRP1(1213-1473):SFV dsRNA intermediate [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9988956] DPP9:NLRP1 binds the C-terminal fragment of NLRP1 [Homo sapiens] [Reaction:9988924] DPP9 binds autoinhibited full-length NLRP1 [Homo sapiens]
relatedSpecies	[Species:9988878] Semliki Forest virus
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9989003] R-HSA-9988992.1
summation	[Summation:9988900] Human NLRP1 directly interacts with long dsRNA (typically >5...
(hasEvent)	[Pathway:9988947] The NLRP1 inflammasome (to replace 844455) [Homo sapiens]
(precedingEvent)	[Reaction:9988970] Pathogen pattern-bound NLRP1 binds ATP (to replace 879222) [Homo sapiens]
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No pathways have been reviewed or authored by NLRP1 senses viral dsRNA (9988992)