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Details on Person DPP9:NLRP1 binds the C-terminal fragment of NLRP1

Class:Id	Reaction:9988956
_displayName	DPP9:NLRP1 binds the C-terminal fragment of NLRP1
_doRelease	FALSE
_timestamp	2026-05-14 01:57:28
created	[InstanceEdit:9988942] Shamovsky, Veronica, 2026-05-14
input	[EntityWithAccessionedSequence:9988926] NLRP1(1213-1473) [cytosol] [Homo sapiens] [Complex:9988959] DPP9, DPP8:NLRP1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9988962] DPP9 sequesters the C�terminus of NLRP1 to repress inflammasome activation [LiteratureReference:9988929] Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding [LiteratureReference:9988983] Structural and biochemical mechanisms of NLRP1 inhibition by DPP9
name	DPP9:NLRP1 binds the C-terminal fragment of NLRP1
output	[Complex:9988921] DPP9, DPP8:NLRP1:NLRP1(1213-1473) [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9988924] DPP9 binds autoinhibited full-length NLRP1 [Homo sapiens] [BlackBoxEvent:9988948] Autoproteolysis of NLRP1 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9989023] R-HSA-9988956.1
summation	[Summation:9988914] The active C-terminal (CT) fragment of NLRP1, consisting of ...
(hasEvent)	[Pathway:9988947] The NLRP1 inflammasome (to replace 844455) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9988918] MDP:NOD2 complex recruits NLRP1 (to replace 844447) [Homo sapiens] [Reaction:9988992] NLRP1 senses viral dsRNA [Homo sapiens]
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No pathways have been reviewed or authored by DPP9:NLRP1 binds the C-terminal fragment of NLRP1 (9988956)