Query author contributions in Reactome
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Details on Person NACHT, LRR, and PYD domain-containing protein 1 (NLRP1) unde...
| Class:Id | Summation:9988951 |
|---|---|
| _displayName | NACHT, LRR, and PYD domain-containing protein 1 (NLRP1) unde... |
| _timestamp | 2026-05-14 01:57:13 |
| created | [InstanceEdit:9988942] Shamovsky, Veronica, 2026-05-14 |
| literatureReference | [LiteratureReference:9988904] CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain [LiteratureReference:9988997] Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity [LiteratureReference:9988980] Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8 [LiteratureReference:9988971] Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation |
| text | NACHT, LRR, and PYD domain-containing protein 1 (NLRP1) undergoes constitutive intramolecular autoproteolysis within its Function-to-find domain (FIIND) at the F1212–S1213 site (D'Osualdo A et al., 2011; Finger JA et al., 2012). This self-cleavage separates the protein into an inhibitory N-terminal fragment, NLRP1 (1–1212), and a C-terminal UPA-CARD fragment, that is competent for inflammasome activation. Following cleavage, these two fragments remain noncovalently associated, maintaining NLRP1 in an autoinhibited state prior to activation. Structural and biochemical studies describe FIIND autoproteolysis as a prerequisite for activation (D'Osualdo A et al., 2011; Finger JA et al., 2012; Zhong FL et al., 2016; Gong Q et al., 2021) |
| (summation) | [BlackBoxEvent:9988948] Autoproteolysis of NLRP1 [Homo sapiens] |
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No pathways have been reviewed or authored by NACHT, LRR, and PYD domain-containing protein 1 (NLRP1) unde... (9988951)
