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Details on Person Autoproteolysis of NLRP1

Class:IdBlackBoxEvent:9988948
_displayNameAutoproteolysis of NLRP1
_doReleaseFALSE
_timestamp2026-05-14 01:57:28
catalystActivity[CatalystActivity:9988901] cysteine-type endopeptidase activity of NLRP1 [cytosol]
catalystActivityReference[CatalystActivityReference:9988936] cysteine-type endopeptidase activity of NLRP1 [cytosol] CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain
compartment[Compartment:70101] cytosol
created[InstanceEdit:9988942] Shamovsky, Veronica, 2026-05-14
input[EntityWithAccessionedSequence:561196] NLRP1 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9988904] CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain
[LiteratureReference:9988997] Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity
nameAutoproteolysis of NLRP1
output[Complex:9988939] NLRP1(1-1212):NLRP1(1213-1473) [cytosol] [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9989008] R-HSA-9988948.1
summation[Summation:9988951] NACHT, LRR, and PYD domain-containing protein 1 (NLRP1) unde...
(hasEvent)[Pathway:9988947] The NLRP1 inflammasome (to replace 844455) [Homo sapiens]
(precedingEvent)[Reaction:9988924] DPP9 binds autoinhibited full-length NLRP1 [Homo sapiens]
[Reaction:9989216] HHV8 ORF45 binds NLRP1 [Homo sapiens]
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