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Details on Person Human NLRP1 directly interacts with long dsRNA (typically >5...
| Class:Id | Summation:9988900 |
|---|---|
| _displayName | Human NLRP1 directly interacts with long dsRNA (typically >5... |
| _timestamp | 2026-05-14 01:57:04 |
| created | [InstanceEdit:9988942] Shamovsky, Veronica, 2026-05-14 |
| literatureReference | [LiteratureReference:9988915] Human NLRP1 is a sensor for double-stranded RNA |
| text | Human NLRP1 directly interacts with long dsRNA (typically >500 base pairs in living cells) through positively charged surface patches on its leucine-rich repeat (LRR) domain. This physical binding triggers potent adenosine triphosphatase (ATPase) activity within the central NACHT domain of NLRP1. The resulting ATP hydrolysis is believed to induce a critical conformational change or "switch" required for downstream inflammasome activity. |
| (summation) | [Reaction:9988992] NLRP1 senses viral dsRNA [Homo sapiens] |
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No pathways have been reviewed or authored by Human NLRP1 directly interacts with long dsRNA (typically >5... (9988900)
