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Details on Person UniProt:P35249 RFC4
| Class:Id | ReferenceGeneProduct:99889 |
|---|---|
| _chainChangeLog | chain:1-363 added on Fri February 6 2015 |
| _displayName | UniProt:P35249 RFC4 |
| _timestamp | 2025-05-21 21:58:03 |
| chain | chain:1-363 |
| checksum | 6FEAB3794379F3E0 |
| comment | FUNCTION Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. The RFC4 subunit probably functions as a scaffold on which the other complex components can assemble.SUBUNIT Subunit of the RFC complex, an heteropentameric complex consisting of a large subunit RFC1 and four small subunits RFC2, RFC3, RFC4 and RFC5; the RFC complex interacts with PCNA (PubMed:8999859, PubMed:9488738, PubMed:39106866). Forms an heterotetrameric complex with RFC2, RFC3 and RFC5; this complex has ATPase activity but is not stimulated by PCNA (PubMed:9488738). The heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 interacts with RAD17 (PubMed:11572977). Interacts with ATAD5(PubMed:39106866). Interacts with CTF18 (PubMed:39106866). Interacts with CNTD1; this interaction facilitates crossover formation (By similarity).INTERACTION The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Despite of the presence of a putative ATP-binding motif, this protein does not bind ATP.SIMILARITY Belongs to the activator 1 small subunits family. |
| description | recommendedName: Replication factor C subunit 4 alternativeName: Activator 1 37 kDa subunit shortName: A1 37 kDa subunit alternativeName: Activator 1 subunit 4 alternativeName: Replication factor C 37 kDa subunit shortName: RF-C 37 kDa subunit shortName: RFC37 |
| geneName | RFC4 |
| identifier | P35249 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Deafness Direct protein sequencing DNA replication Nucleotide-binding Nucleus Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | RFC4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003769] ENSEMBL:ENSG00000163918 RFC4 [Homo sapiens] |
| secondaryIdentifier | RFC4_HUMAN B4DM41 D3DNV2 Q6FHX7 |
| sequenceLength | 363 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8976719] UniProt:P35249-1 RFC4 [Homo sapiens] [ReferenceIsoform:8976720] UniProt:P35249-2 RFC4 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:68429] RFC4 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P35249 RFC4 (99889)
