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Details on Person PHF6 is a nucleolar and chromatin-associated PHD finger prot...

Class:IdSummation:9988506
_displayNamePHF6 is a nucleolar and chromatin-associated PHD finger prot...
_timestamp2026-05-07 17:34:52
created[InstanceEdit:9988505] Rothfels, Karen, 2026-05-07
textPHF6 is a nucleolar and chromatin-associated PHD finger protein that participates in transcriptional regulation through interactions with multiple ATP-dependent chromatin remodeling complexes, including members of the SWI/SNF family (Alvarez et al, 2022; Kubota et al, 2024; Mittal et al, 2024). Proteomic and biochemical studies in human cells demonstrated that PHF6 associates with components of the ncBAF and PBAF SWI/SNF subcomplexes, including SMARCA4/BRG1, BRD9, and PBRM1, and reciprocal co-immunoprecipitation experiments confirmed a physical interaction between endogenous PHF6 and these remodeling complexes (Alvarez et al, 2022; Mittal et al, 2024; Kubota et al, 2024). Loss of PHF6 reduces recruitment or stability of SWI/SNF bromodomain-containing subunits at promoter regions and alters chromatin accessibility and transcriptional elongation, supporting a role for PHF6 in coordinating chromatin remodeling with transcriptional activation (Mittal et al, 2024). Earlier studies also linked PHF6 to transcriptional regulation through interactions with additional chromatin remodeling complexes including NuRD and ISWI, suggesting that PHF6 functions broadly as a chromatin adaptor or scaffold protein (Soto-Feliciano et al, 2017; Todd and Picketts, 2012; Liu et al, 2015; reviewed in Todd et al, 2015).
(summation)[Reaction:9988507] PHF6 binds SWI/SNF complexes [Homo sapiens]
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