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Details on Person After translation starts, the signal peptide or signal ancho...
| Class:Id | Summation:9988199 |
|---|---|
| _displayName | After translation starts, the signal peptide or signal ancho... |
| _timestamp | 2026-05-14 16:16:25 |
| created | [InstanceEdit:9988191] May, Bruce, 2026-05-05 |
| literatureReference | [LiteratureReference:9729793] Signal recognition particle: an essential protein-targeting machine [LiteratureReference:445200] Following the signal sequence from ribosomal tunnel exit to signal recognition particle [LiteratureReference:9989041] Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein [LiteratureReference:9989043] Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes |
| modified | [InstanceEdit:9988283] May, Bruce, 2026-05-05 [InstanceEdit:9988655] May, Bruce, 2026-05-09 [InstanceEdit:9988772] May, Bruce, 2026-05-12 [InstanceEdit:9988773] May, Bruce, 2026-05-12 [InstanceEdit:9989044] May, Bruce, 2026-05-14 |
| text | After translation starts, the signal peptide or signal anchor of the nascent polypeptide protrudes from the exit tunnel of the ribosome and is bound by the SRP54 subunit of the signal recognition particle (SRP) (Lakkaraju et al. 2008, Voorhees and Hegde 2015, Lee et al. 2018, Lee et al. 2021, inferred from canine homologs in Walter et al. 1981, Halic et al. 2006, reviewed in Nagai et al. 2003, Akopian et al. 2013). A signal peptide is a short (~20 amino acid residue) hydrophobic region at the N-terminus of an endoplasmic reticulum-targeted (ER-targeted) protein that is cleaved during the translocation of the protein across the ER membrane. A signal anchor is also a hydrophobic region, however it is not cleaved and remains embedded as a transmembrane domain in the ER membrane after translocation. The binding of the SRP arrests translation elongation (inferred from canine homologs in Walter and Blobel 1981). |
| (summation) | [Reaction:9988100] Nascent ER-targeted polypeptide:80S ribosome:mRNA binds signal recognition particle (SRP):GTP [Homo sapiens] |
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No pathways have been reviewed or authored by After translation starts, the signal peptide or signal ancho... (9988199)
