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Details on Person SEC61 translocon:TRAP complex translocates soluble ER-targeted protein into the ER lumen

Class:Id	BlackBoxEvent:9988097
_displayName	SEC61 translocon:TRAP complex translocates soluble ER-targeted protein into the ER lumen
_timestamp	2026-05-12 16:06:28
authored	[InstanceEdit:9988091] May, Bruce, 2026-04-30
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9988101] May, Bruce, 2026-05-03
edited	[InstanceEdit:9988091] May, Bruce, 2026-04-30
inferredFrom	[Reaction:9988757] Sec61 translocon (canine) translocates Preprolactin (bovine) [Bos taurus]
input	[Complex:9988086] SEC61 translocon:TRAP:nascent soluble ER polypeptide minus signal peptide:80S ribosome:mRNA [Homo sapiens]
isChimeric	FALSE
modified	[InstanceEdit:9988168] May, Bruce, 2026-05-04 [InstanceEdit:9988772] May, Bruce, 2026-05-12
name	SEC61 translocon:TRAP complex translocates soluble ER-targeted protein into the ER lumen
output	[Complex:264969] Translocon:TRAP [endoplasmic reticulum membrane] [Homo sapiens] [GenomeEncodedEntity:72323] mRNA [cytosol] [Homo sapiens] [DefinedSet:9988081] soluble ER protein [endoplasmic reticulum lumen] [Homo sapiens] [Complex:72392] 40S ribosomal complex [cytosol] [Homo sapiens] [Complex:72499] 60S ribosomal complex [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9988102] Signal peptidase cleaves signal peptide from nascent polypeptide during translation [Homo sapiens] [Reaction:9988089] SRP:GTP:SRP receptor:GTP transfers nascent polypeptide containing signal peptide or signal anchor to SEC61 translocon:TRAP complex [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9988120] R-HSA-9988097.1
structureModified	[InstanceEdit:9988168] May, Bruce, 2026-05-04
summation	[Summation:9988764] After cleavage of the signal peptide by the signal peptidase...
(hasEvent)	[Pathway:9986646] Cotranslational targeting of proteins to the endoplasmic reticulum [Homo sapiens]
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No pathways have been reviewed or authored by SEC61 translocon:TRAP complex translocates soluble ER-targeted protein into the ER lumen (9988097)