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Details on Person UniProt:P35250 RFC2
| Class:Id | ReferenceGeneProduct:99880 |
|---|---|
| _chainChangeLog | chain:1-354 added on Fri February 6 2015 |
| _displayName | UniProt:P35250 RFC2 |
| _timestamp | 2025-05-21 21:14:35 |
| chain | chain:1-354 |
| checksum | B50AC8EEF89F64A9 |
| comment | FUNCTION Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds ATP (By similarity).SUBUNIT Subunit of the RFC complex, an heteropentameric complex consisting of a large subunit RFC1 and four small subunits RFC2, RFC3, RFC4 and RFC5; the RFC complex interacts with PCNA (PubMed:8999859, PubMed:9488738). Forms an heterotetrameric complex with RFC3, RFC4 and RFC5; this complex has ATPase activity but is not stimulated by PCNA (PubMed:9488738). The heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 interacts with RAD17 (PubMed:11572977). RFC2 also interacts with PRKAR1A; the complex may be involved in cell survival (PubMed:15655353). Interacts with DDX11 (PubMed:18499658).INTERACTION RFC2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region (PubMed:11003705).SIMILARITY Belongs to the activator 1 small subunits family. |
| description | recommendedName: Replication factor C subunit 2 alternativeName: Activator 1 40 kDa subunit shortName: A1 40 kDa subunit alternativeName: Activator 1 subunit 2 alternativeName: Replication factor C 40 kDa subunit shortName: RF-C 40 kDa subunit shortName: RFC40 |
| geneName | RFC2 |
| identifier | P35250 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Direct protein sequencing DNA replication Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Williams-Beuren syndrome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | RFC2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995085] ENSEMBL:ENSG00000049541 RFC2 [Homo sapiens] |
| secondaryIdentifier | RFC2_HUMAN B5BU07 D3DXG3 P32846 Q9BU93 |
| sequenceLength | 354 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:152867] UniProt:P35250-2 RFC2 [Homo sapiens] [ReferenceIsoform:403804] UniProt:P35250-1 RFC2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:68433] RFC2 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P35250 RFC2 (99880)
