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Details on Person UniProt:P35251 RFC1
| Class:Id | ReferenceGeneProduct:99875 |
|---|---|
| _chainChangeLog | chain:1-1148 added on Fri February 6 2015 |
| _displayName | UniProt:P35251 RFC1 |
| _timestamp | 2025-05-21 21:20:48 |
| chain | chain:1-1148 |
| checksum | 485F0332FB56819B |
| comment | FUNCTION Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA.SUBUNIT Large subunit of the RFC complex, an heteropentameric complex consisting of RFC1 and four small subunits RFC2, RFC3, RFC4 and RFC5; the RFC complex interacts with PCNA and the interaction involves RFC1 (PubMed:8999859, PubMed:9488738).INTERACTION Wide tissue distribution. Undetectable in placental tissue.DISEASE The disease is caused by variants affecting the gene represented in this entry. The disease is caused by intronic AAGGG repeat expansions in intron 2.MISCELLANEOUS Alternative use of an acceptor site.SIMILARITY Belongs to the activator 1 large subunit family. |
| description | recommendedName: Replication factor C subunit 1 alternativeName: Activator 1 140 kDa subunit shortName: A1 140 kDa subunit alternativeName: Activator 1 large subunit alternativeName: Activator 1 subunit 1 alternativeName: DNA-binding protein PO-GA alternativeName: Replication factor C 140 kDa subunit shortName: RF-C 140 kDa subunit shortName: RFC140 alternativeName: Replication factor C large subunit |
| geneName | RFC1 RFC140 |
| identifier | P35251 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Alternative splicing ATP-binding Direct protein sequencing DNA replication DNA-binding Isopeptide bond Neuropathy Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | RFC1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003768] ENSEMBL:ENSG00000035928 RFC1 [Homo sapiens] |
| secondaryIdentifier | RFC1_HUMAN A8K6E7 Q5XKF5 Q6PKU0 Q86V41 Q86V46 |
| sequenceLength | 1148 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:152865] UniProt:P35251-2 RFC1 [Homo sapiens] [ReferenceIsoform:403805] UniProt:P35251-1 RFC1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:68435] RFC1 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P35251 RFC1 (99875)
