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Details on Person D'Eustachio, Peter, 2026-04-10

Class:IdInstanceEdit:9987236
_displayNameD'Eustachio, Peter, 2026-04-10
_timestamp2026-04-10 21:51:01
author[Person:140934] D'Eustachio, Peter
dateTime2026-04-10 21:50:55
(created)[Complex:9987227] SREBP1A,1C,NF-Y,SP1 [nucleoplasm] [Homo sapiens]
[Complex:9987228] SREBP1A,2,SP1 [nucleoplasm] [Homo sapiens]
[CatalystActivity:9987229] DNA-binding transcription activator activity, RNA polymerase II-specific of SREBP1A,2,SP1 [nucleoplasm]
[CatalystActivity:9987230] DNA-binding transcription activator activity, RNA polymerase II-specific of SREBP1A,1C,NF-Y,SP1 [nucleoplasm]
[CatalystActivityReference:9987231] DNA-binding transcription activator activity, RNA polymerase II-specific of SREBP1A,1C,NF-Y,SP1 [nucleoplasm] Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites
[CatalystActivity:9987232] DNA-binding transcription activator activity, RNA polymerase II-specific of SREBP1A,2,NF-Y,SP1 [nucleoplasm]
[CatalystActivity:9987233] DNA-binding transcription activator activity, RNA polymerase II-specific of SREBP1A,1C,NF-Y [nucleoplasm]
[CatalystActivityReference:9987234] protein sequestering activity of SREBP1A,1C,2:SCAP [endoplasmic reticulum membrane] Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro
[CatalystActivityReference:9987235] cargo adaptor activity of SREBP1A,1C,2:SCAP [endoplasmic reticulum membrane] Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs
[CatalystActivityReference:9987237] DNA-binding transcription activator activity, RNA polymerase II-specific of SREBP1A,1C dimer [nucleoplasm] Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins
List all 33 refering instances
(modified)[Reaction:1655825] SREBP1A,1C,2:SCAP binds CopII Coat Complex [Homo sapiens]
[PathwayDiagram:1660554] Diagram of Regulation of cholesterol biosynthesis by SREBP (SREBF)
[Reaction:2065966] SREBP1A,1C,2 binds the TM7SF2 promoter [Homo sapiens]
[Reaction:2317530] SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum [Homo sapiens]
[Reaction:2317531] SREBP1A,1C,2 binds SCAP:INSIG:oxysterol and is retained in the endoplasmic reticulum [Homo sapiens]
[Reaction:2426144] SREBP1A,2 binds the MVD promoter [Homo sapiens]
[Reaction:2426148] SREBP1A,1C binds the FASN promoter [Homo sapiens]
[Reaction:2426152] SREBP1A,2 binds the IDI1 promoter [Homo sapiens]
[Reaction:2426153] SREBP1A,1C binds the ACACB promoter [Homo sapiens]
[Reaction:2426154] SREBP1A,2 binds the LSS promoter [Homo sapiens]
List all 22 refering instances
(structureModified)[Reaction:1655825] SREBP1A,1C,2:SCAP binds CopII Coat Complex [Homo sapiens]
[Reaction:2065966] SREBP1A,1C,2 binds the TM7SF2 promoter [Homo sapiens]
[Reaction:2317530] SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum [Homo sapiens]
[Reaction:2317531] SREBP1A,1C,2 binds SCAP:INSIG:oxysterol and is retained in the endoplasmic reticulum [Homo sapiens]
[Reaction:2426144] SREBP1A,2 binds the MVD promoter [Homo sapiens]
[Reaction:2426148] SREBP1A,1C binds the FASN promoter [Homo sapiens]
[Reaction:2426152] SREBP1A,2 binds the IDI1 promoter [Homo sapiens]
[Reaction:2426153] SREBP1A,1C binds the ACACB promoter [Homo sapiens]
[Reaction:2426154] SREBP1A,2 binds the LSS promoter [Homo sapiens]
[Reaction:2426155] SREBP1A,2 binds the DHCR7 promoter [Homo sapiens]
List all 19 refering instances
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No pathways have been reviewed or authored by D'Eustachio, Peter, 2026-04-10 (9987236)
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