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Details on Person After recognizing the N-terminus of a nascent membrane prote...
| Class:Id | Summation:9986870 |
|---|---|
| _displayName | After recognizing the N-terminus of a nascent membrane prote... |
| _timestamp | 2026-05-12 17:12:06 |
| created | [InstanceEdit:9986866] May, Bruce, 2026-04-06 |
| literatureReference | [LiteratureReference:9986941] Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane [LiteratureReference:9987156] The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer [LiteratureReference:9987155] Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion [LiteratureReference:9987147] The lateral gate of SecYEG opens during protein translocation |
| modified | [InstanceEdit:9986963] May, Bruce, 2026-04-07 [InstanceEdit:9987052] May, Bruce, 2026-04-09 [InstanceEdit:9987160] May, Bruce, 2026-04-10 [InstanceEdit:9988773] May, Bruce, 2026-05-12 |
| text | After recognizing the N-terminus of a nascent membrane protein, the SEC61 translocon:TRAP complex translocates the nascent polypeptide through channel across the endoplasmic reticulum (ER) membrane. When a transmembrane domain (TMD) in the nascent polypeptide emerges from the 80S ribosome, the TMD enters the channel of the SEC61A:SEC61B:SEC61G trimer and is then transferred laterally into the ER membrane (Gemmer et al. 2023, Lewis et al. 2024, and inferred from canine homologs in Görlich and Rapoport 1993, Martoglio et al. 1995, Gogala et al. 2014, inferred from E. coli homologs in du Plessis et al. 2009, reviewed in Itskanov and Park 2023) through a gate between transmembrane helices of the SEC61A subunit (inferred from canine homologs in Gogala et al. 2014) that is controlled by SERP1 (RAMP4) (Lewis et al. 2024). |
| (summation) | [BlackBoxEvent:9986727] SEC61 translocon:TRAP inserts protein into endoplasmic reticulum membrane [Homo sapiens] |
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No pathways have been reviewed or authored by After recognizing the N-terminus of a nascent membrane prote... (9986870)
