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Details on Person SRP:SRP receptor transfers nascent membrane polypeptide to SEC61 translocon:TRAP complex

Class:Id	Reaction:9986704
_displayName	SRP:SRP receptor transfers nascent membrane polypeptide to SEC61 translocon:TRAP complex
_timestamp	2026-05-04 18:13:54
authored	[InstanceEdit:9986701] May, Bruce, 2026-04-04
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9986705] May, Bruce, 2026-04-04
edited	[InstanceEdit:9986701] May, Bruce, 2026-04-04
inferredFrom	[Reaction:445275] Translocon (canine) binds Preprolactin (bovine) [Bos taurus]
input	[Complex:9986706] SRP receptor:GTP:SRP:GTP:nascent ER-targeted polypeptide:80S ribosome:mRNA [endoplasmic reticulum membrane] [Homo sapiens] [Complex:264969] Translocon:TRAP [endoplasmic reticulum membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9986827] Identification of a factor that accelerates substrate release from the signal recognition particle [LiteratureReference:9986829] Mechanism of signal-anchor triage during early steps of membrane protein insertion [LiteratureReference:9986948] Visualization of translation and protein biogenesis at the ER membrane
modified	[InstanceEdit:9986856] May, Bruce, 2026-04-06 [InstanceEdit:9986953] May, Bruce, 2026-04-07 [InstanceEdit:9987052] May, Bruce, 2026-04-09 [InstanceEdit:9988168] May, Bruce, 2026-05-04
name	SRP:SRP receptor transfers nascent membrane polypeptide to SEC61 translocon:TRAP complex
output	[Complex:265092] SRP receptor [endoplasmic reticulum membrane] [Homo sapiens] [Complex:264932] Signal Recognition Particle [cytosol] [Homo sapiens] [Complex:9986696] SEC61 translocon:TRAP:nascent membrane polypeptide:80S ribosome:mRNA [endoplasmic reticulum membrane] [Homo sapiens]
regulatedBy	[PositiveRegulation:9986841] Positive regulation by 'TMEM208 [cytosol]'
regulationReference	[RegulationReference:9986831] Positive regulation by 'TMEM208 [cytosol]' Identification of a factor that accelerates substrate release from the signal recognition particle
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9986718] R-HSA-9986704.1
structureModified	[InstanceEdit:9986856] May, Bruce, 2026-04-06 [InstanceEdit:9987052] May, Bruce, 2026-04-09
summation	[Summation:9986950] Signal peptides (cleavable hydrophobic N-termini) and signal...
(precedingEvent)	[Reaction:9986702] SEC61 translocon:TRAP:nascent membrane polypeptide binds BOS, PAT, and GEL complexes yielding the multipass transmembrane translocon (MPT) [Homo sapiens] [BlackBoxEvent:9986727] SEC61 translocon:TRAP inserts protein into endoplasmic reticulum membrane [Homo sapiens] [Reaction:9987039] SEC61 translocon:TRAP:nascent membrane polypeptide binds OST complex [Homo sapiens]
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No pathways have been reviewed or authored by SRP:SRP receptor transfers nascent membrane polypeptide to SEC61 translocon:TRAP complex (9986704)