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Details on Person SEC61 translocon:TRAP:nascent membrane polypeptide binds BOS, PAT, and GEL complexes yielding the multipass transmembrane translocon (MPT)

Class:Id	Reaction:9986702
_displayName	SEC61 translocon:TRAP:nascent membrane polypeptide binds BOS, PAT, and GEL complexes yielding the multipass transmembrane translocon (MPT)
_timestamp	2026-05-04 18:13:44
authored	[InstanceEdit:9986701] May, Bruce, 2026-04-04
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9986705] May, Bruce, 2026-04-04
edited	[InstanceEdit:9986701] May, Bruce, 2026-04-04
input	[Complex:8932554] BOS complex [endoplasmic reticulum membrane] [Homo sapiens] [Complex:9986647] GEL complex [endoplasmic reticulum membrane] [Homo sapiens] [Complex:9986650] PAT complex [endoplasmic reticulum membrane] [Homo sapiens] [Complex:9988106] SEC61 translocon:TRAP:nascent multipass ER membrane polypeptide:80S ribosome:mRNA [endoplasmic reticulum membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9986708] Substrate-driven assembly of a translocon for multipass membrane proteins [LiteratureReference:9986948] Visualization of translation and protein biogenesis at the ER membrane [LiteratureReference:9987005] Exploring the molecular composition of the multipass translocon in its native membrane environment [LiteratureReference:9987016] Global analysis of translocon remodeling during protein synthesis at the ER
modified	[InstanceEdit:9986953] May, Bruce, 2026-04-07 [InstanceEdit:9986963] May, Bruce, 2026-04-07 [InstanceEdit:9987052] May, Bruce, 2026-04-09 [InstanceEdit:9988141] May, Bruce, 2026-05-03 [InstanceEdit:9988168] May, Bruce, 2026-05-04
name	SEC61 translocon:TRAP:nascent membrane polypeptide binds BOS, PAT, and GEL complexes yielding the multipass transmembrane translocon (MPT)
output	[Complex:9986700] Translocon:TRAP:MPT:nascent multipass ER membrane polypeptide:80S ribosome:mRNA [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent	[Reaction:9986704] SRP:SRP receptor transfers nascent membrane polypeptide to SEC61 translocon:TRAP complex [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9986717] R-HSA-9986702.1
structureModified	[InstanceEdit:9987052] May, Bruce, 2026-04-09 [InstanceEdit:9988141] May, Bruce, 2026-05-03
summation	[Summation:9986961] Analysis of intermediates during insertion of multipass memb...
(hasEvent)	[Pathway:9986646] Cotranslational targeting of proteins to the endoplasmic reticulum [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9986731] Multipass translocon (MPT) inserts protein into endoplasmic reticulum membrane [Homo sapiens]
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No pathways have been reviewed or authored by SEC61 translocon:TRAP:nascent membrane polypeptide binds BOS, PAT, and GEL complexes yielding the multipass transmembrane translocon (MPT) (9986702)