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Details on Person TFB2M binds POLRMT:TFAM:mitochondrial promoter complex

Class:Id	Reaction:9986213
_displayName	TFB2M binds POLRMT:TFAM:mitochondrial promoter complex
_timestamp	2026-04-24 17:10:22
authored	[InstanceEdit:163227] Gustafsson, C, 2005-04-25 22:00:00 [InstanceEdit:9986209] May, Bruce, 2026-03-27
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9986212] May, Bruce, 2026-03-27
edited	[InstanceEdit:9986209] May, Bruce, 2026-03-27
input	[EntityWithAccessionedSequence:163272] TFB2M [mitochondrial matrix] [Homo sapiens] [Complex:9986300] POLRMT:TFAM:mitochondrial promoter [mitochondrial matrix] [Homo sapiens]
literatureReference	[LiteratureReference:163222] Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA [LiteratureReference:163313] The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells [LiteratureReference:9985720] Structural Basis of Mitochondrial Transcription Initiation [LiteratureReference:9986211] TFB2 is a transient component of the catalytic site of the human mitochondrial RNA polymerase [LiteratureReference:9986236] Organization of the human mitochondrial transcription initiation complex [LiteratureReference:9986237] A novel intermediate in transcription initiation by human mitochondrial RNA polymerase [LiteratureReference:9986221] Human mitochondrial transcription factors TFAM and TFB2M work synergistically in promoter melting during transcription initiation [LiteratureReference:9986231] A model for transcription initiation in human mitochondria [LiteratureReference:9986308] Human Mitochondrial Transcription Factor B2 Is Required for Promoter Melting during Initiation of Transcription
modified	[InstanceEdit:9986239] May, Bruce, 2026-03-27 [InstanceEdit:9986311] May, Bruce, 2026-03-29 [InstanceEdit:9987674] May, Bruce, 2026-04-24
name	TFB2M binds POLRMT:TFAM:mitochondrial promoter complex
output	[Complex:163307] POLRMT:TFB2M:TFAM:mitochondrial promoter [mitochondrial matrix] [Homo sapiens]
precedingEvent	[BlackBoxEvent:1592252] Expression of TFB2M [Homo sapiens] [Reaction:2466367] NRF1, PPRC1:HCFC1:NRF2 bind the TFB2M promoter [Homo sapiens] [Reaction:2466392] NRF1:p-PPARGC1A, NRF2 bind the TFB2M promoter [Homo sapiens] [Reaction:9986307] POLRMT binds TFAM:mitochondrial promoter [Homo sapiens] [Reaction:163310] TFAM binds to mitochondrial promoters [Homo sapiens] [BlackBoxEvent:1592243] Expression of POLRMT [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9986216] R-HSA-9986213.1
structureModified	[InstanceEdit:9986311] May, Bruce, 2026-03-29
summation	[Summation:9986226] TFB2M binds POLRMT and TFAM at the promoter, forming the ini...
(hasEvent)	[Pathway:9985686] Mitochondrial transcription [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9985667] POLRMT in POLRMT:TFB2M:TFAM:mitochondrial promoter polymerizes 5 nt RNA and TFAM dissociates [Homo sapiens]
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