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Details on Person TEFM:POLRMT:mitochondrial genome:H,L strand transcript contacts MTERF1

Class:Id	Reaction:9986199
_displayName	TEFM:POLRMT:mitochondrial genome:H,L strand transcript contacts MTERF1
_timestamp	2026-03-30 16:40:32
authored	[InstanceEdit:9985775] May, Bruce, 2026-03-26
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9986192] May, Bruce, 2026-03-27
edited	[InstanceEdit:9985775] May, Bruce, 2026-03-26
input	[Complex:9985683] POLRMT:TEFM:mitochondrial genome:H,L strand transcript [mitochondrial matrix] [Homo sapiens] [Complex:163321] MTERF1:mitochondrial transcription termination sequence [mitochondrial matrix] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:163255] Termination of transcription in human mitochondria: identification and purification of a DNA binding protein factor that promotes termination [LiteratureReference:164553] The human mitochondrial transcription termination factor (mTERF) is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions [LiteratureReference:9985736] Helix unwinding and base flipping enable human MTERF1 to terminate mitochondrial transcription [LiteratureReference:163265] Molecular characterization of the transcription termination factor from human mitochondria [LiteratureReference:9986200] In vivo methylation of mtDNA reveals the dynamics of protein-mtDNA interactions [LiteratureReference:164547] Human mitochondrial transcription termination exhibits RNA polymerase independence and biased bipolarity in vitro [LiteratureReference:9986195] The human mitochondrial transcription termination factor (mTERF) is fully active in vitro in the non-phosphorylated form
modified	[InstanceEdit:9986239] May, Bruce, 2026-03-27 [InstanceEdit:9986361] May, Bruce, 2026-03-30
name	TEFM:POLRMT:mitochondrial genome:H,L strand transcript contacts MTERF1
output	[Complex:9986203] POLRMT:TEFM:mitochondrial genome:H,L strand transcript:MTERF1 [mitochondrial matrix] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9985671] POLRMT in the complex POLRMT:TEFM:mitochondrial genome:8-9 nt RNA polymerizes mitochondrial H,L strand transcript [Homo sapiens] [Reaction:9985674] TEFM binds POLRMT:mitochondrial genome:8-9 nt RNA [Homo sapiens] [Reaction:163320] Association of MTERF1 (mTERF) with the termination sequence [Homo sapiens] [Reaction:163296] Association of TFAM:mt promoter complex with POLRMT:TFB2M [Homo sapiens] [BlackBoxEvent:1592251] Expression of MTERF1 (mTERF) [Homo sapiens] [BlackBoxEvent:9985671] POLRMT in the complex POLRMT:TEFM:mitochondrial genome:8-9 nt RNA polymerizes mitochondrial H,L strand transcript [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9986208] R-HSA-9986199.1
summation	[Summation:9986345] Elongation complexes (POLRMT:TEFM) that are polymerizing the...
(hasEvent)	[Pathway:9985686] Mitochondrial transcription [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9986204] POLRMT:TEFM:mitochondrial genome:H,L strand transcript:MTERF1 dissociates [Homo sapiens]
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No pathways have been reviewed or authored by TEFM:POLRMT:mitochondrial genome:H,L strand transcript contacts MTERF1 (9986199)