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Details on Person ORF50 ubiquitinates ZNF426

Class:Id	BlackBoxEvent:9985508
_displayName	ORF50 ubiquitinates ZNF426
_doRelease	FALSE
_timestamp	2026-03-23 08:56:35
authored	[InstanceEdit:9985311] Stephan, Ralf, 2026-03-18
catalystActivity	[CatalystActivity:9984422] ubiquitin protein ligase activity of p-ORF50 tetramer [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9985504] Stephan, Ralf, 2026-03-20
disease	[Disease:3134794] viral infectious disease
goBiologicalProcess	[GO_BiologicalProcess:22583] protein polyubiquitination
input	[EntityWithAccessionedSequence:1247530] ZNF426 [nucleoplasm] [Homo sapiens] [Complex:9977380] p-ORF50 tetramer [nucleoplasm] [Human herpesvirus 8]
isChimeric	FALSE
literatureReference	[LiteratureReference:9985509] The transcriptional repressor K-RBP modulates RTA-mediated transactivation and lytic replication of Kaposi's sarcoma-associated herpesvirus [LiteratureReference:9985506] Kaposi's sarcoma-associated herpesvirus transactivator RTA promotes degradation of the repressors to regulate viral lytic replication
modified	[InstanceEdit:9985631] Stephan, Ralf, 2026-03-23
name	ORF50 ubiquitinates ZNF426
output	[EntityWithAccessionedSequence:9985505] Ub-ZNF426 [nucleoplasm] [Homo sapiens] [Complex:9977380] p-ORF50 tetramer [nucleoplasm] [Human herpesvirus 8]
precedingEvent	[BlackBoxEvent:9985134] ORF50 and ITCH ubiquitinate ORF71 [Homo sapiens] [BlackBoxEvent:9985508] ORF50 ubiquitinates ZNF426 [Homo sapiens]
relatedSpecies	[Species:2671781] Human herpesvirus 8
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9985512] R-HSA-9985508.1
summation	[Summation:9985507] HHV8 ORF50 protein (RTA) binds to and probably poly-ubiquiti...
(hasEvent)	[Pathway:9976097] Establishment of Lytic HHV8 Infection [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9984375] ORF50 ubiquitinates ZIC2 [Homo sapiens] [Reaction:9984981] NCOA2 stabilizes ORF50 [Homo sapiens] [Reaction:9984992] ORF50 binds to ORF50 promoter [Homo sapiens] [BlackBoxEvent:9985006] MDM2 polyubiquitinates p-ORF50 tetramer [Homo sapiens] [BlackBoxEvent:9985134] ORF50 and ITCH ubiquitinate ORF71 [Homo sapiens]
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No pathways have been reviewed or authored by ORF50 ubiquitinates ZNF426 (9985508)