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Details on Person PIM1,3 phosphorylate LANA1

Class:IdReaction:9985163
_displayNamePIM1,3 phosphorylate LANA1
_doReleaseFALSE
_timestamp2026-03-23 08:57:11
authored[InstanceEdit:9985151] Stephan, Ralf, 2026-03-16
catalystActivity[CatalystActivity:9985161] protein serine/threonine kinase activity of PIM1,3 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9985162] Stephan, Ralf, 2026-03-16
crossReference[DatabaseIdentifier:9857128] RHEA:17990
disease[Disease:3134794] viral infectious disease
goBiologicalProcess[GO_BiologicalProcess:3601] protein phosphorylation
input[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[Complex:9978636] Me-R20-p-S10,T14-LANA1 dimer [nucleoplasm] [Human herpesvirus 8]
isChimericFALSE
literatureReference[LiteratureReference:9985178] KSHV encoded LANA upregulates Pim-1 and is a substrate for its kinase activity
[LiteratureReference:9985173] KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA
[LiteratureReference:9976831] Post-Translational Modifications of Kaposi's Sarcoma-Associated Herpesvirus Regulatory Proteins - SUMO and KSHV
modified[InstanceEdit:9985631] Stephan, Ralf, 2026-03-23
namePIM1,3 phosphorylate LANA1
output[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[Complex:9985171] Me-R20-p-S10,T14,S205,S206-LANA1 dimer [nucleoplasm] [Human herpesvirus 8]
precedingEvent
relatedSpecies[Species:2671781] Human herpesvirus 8
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9985182] R-HSA-9985163.1
summation[Summation:9985177] Host Serine/threonine-protein kinases PIM1 and PIM3 phosphor...
(hasEvent)[Pathway:9976097] Establishment of Lytic HHV8 Infection [Homo sapiens]
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