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Details on Person LANA1 dissociates from episome

Class:Id	Reaction:9985155
_displayName	LANA1 dissociates from episome
_doRelease	FALSE
_timestamp	2026-03-23 08:55:08
authored	[InstanceEdit:9985137] Stephan, Ralf, 2026-03-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9985151] Stephan, Ralf, 2026-03-16
disease	[Disease:3134794] viral infectious disease
input	[Complex:9981981] Me-R20-LANA1 Oligomer:HHV8 Circular Episome:Condensed prophase chromosome [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9985154] A lytic viral long noncoding RNA modulates the function of a latent protein [LiteratureReference:9983397] Site-specific association with host and viral chromatin by Kaposi's sarcoma-associated herpesvirus LANA and its reversal during lytic reactivation
modified	[InstanceEdit:9985631] Stephan, Ralf, 2026-03-23
name	LANA1 dissociates from episome
output	[Complex:9982061] Condensed prophase chromosome [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9979916] HHV8 Circular Episome [nucleoplasm] [Human herpesvirus 8] [Complex:9978636] Me-R20-p-S10,T14-LANA1 dimer [nucleoplasm] [Human herpesvirus 8]
precedingEvent	[Reaction:9984378] Dissociation of PRC2 from episome [Homo sapiens] [Reaction:9984401] Activated RPS6KA5 phosphorylates H3K27me3 [Homo sapiens] [BlackBoxEvent:9984375] ORF50 ubiquitinates ZIC2 [Homo sapiens] [Reaction:9985150] PAN RNA binds to LANA1 [Homo sapiens] [Reaction:9984378] Dissociation of PRC2 from episome [Homo sapiens]
regulatedBy	[PositiveRegulation:9985152] Positive regulation by 'PAN RNA:Me-R20-LANA1 Oligomer:HHV8 Circular Episome:Condensed prophase chromosome [nucleoplasm]'
relatedSpecies	[Species:2671781] Human herpesvirus 8
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9985159] R-HSA-9985155.1
summation	[Summation:9985157] HHV8 LANA1 dissociates from episomes during lytic reactivati...
(hasEvent)	[Pathway:9976097] Establishment of Lytic HHV8 Infection [Homo sapiens]
(precedingEvent)	[Reaction:9985163] PIM1,3 phosphorylate LANA1 [Homo sapiens]
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No pathways have been reviewed or authored by LANA1 dissociates from episome (9985155)