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Details on Person ORF50 binds to ORF50 promoter

Class:Id	Reaction:9984992
_displayName	ORF50 binds to ORF50 promoter
_doRelease	FALSE
_timestamp	2026-03-23 08:56:09
authored	[InstanceEdit:9984995] Stephan, Ralf, 2026-03-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984987] Stephan, Ralf, 2026-03-13
disease	[Disease:3134794] viral infectious disease
input	[Complex:9977380] p-ORF50 tetramer [nucleoplasm] [Human herpesvirus 8] [Complex:9984979] ORF50 gene:H3K4me3,H3K27ac-Nucleosome:PAN RNA [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9985028] KSHV RTA utilizes the host E3 ubiquitin ligase complex RNF20/40 to drive lytic reactivation [LiteratureReference:9982108] Genome-wide identification of binding sites for Kaposi's sarcoma-associated herpesvirus lytic switch protein, RTA [LiteratureReference:9984984] CCAAT/enhancer-binding protein-alpha is induced during the early stages of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic cycle reactivation and together with the KSHV replication and transcription activator (RTA) cooperatively stimulates the viral RTA, MTA, and PAN promoters [LiteratureReference:9984967] Genome-Wide Identification of Direct RTA Targets Reveals Key Host Factors for Kaposi's Sarcoma-Associated Herpesvirus Lytic Reactivation
modified	[InstanceEdit:9985631] Stephan, Ralf, 2026-03-23
name	ORF50 binds to ORF50 promoter
output	[Complex:9984970] ORF50 gene:H3K4me3,H3K27ac-Nucleosome:PAN RNA:ORF50 [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9985134] ORF50 and ITCH ubiquitinate ORF71 [Homo sapiens] [BlackBoxEvent:9985508] ORF50 ubiquitinates ZNF426 [Homo sapiens] [BlackBoxEvent:9985508] ORF50 ubiquitinates ZNF426 [Homo sapiens] [BlackBoxEvent:9985134] ORF50 and ITCH ubiquitinate ORF71 [Homo sapiens] [Reaction:9984971] SIRT1 dissociates from ORF50 promoter [Homo sapiens] [Reaction:9984968] CREBBP,EP300 acetylates H3 [Homo sapiens]
relatedSpecies	[Species:2671781] Human herpesvirus 8
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9985041] R-HSA-9984992.1
summation	[Summation:9985004] HHV8 Replication and transcription activator (ORF50, RTA) bi...
(hasEvent)	[Pathway:9976097] Establishment of Lytic HHV8 Infection [Homo sapiens]
(precedingEvent)	[Reaction:9985111] ORF50 recruits RNF20/40 [Homo sapiens] [BlackBoxEvent:9985122] RNF20/40 ubiquitinates H2B [Homo sapiens]
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No pathways have been reviewed or authored by ORF50 binds to ORF50 promoter (9984992)