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Details on Person KDM6A,B demethylates H3K27

Class:IdReaction:9984982
_displayNameKDM6A,B demethylates H3K27
_doReleaseFALSE
_timestamp2026-03-23 08:54:59
authored[InstanceEdit:9984995] Stephan, Ralf, 2026-03-11
catalystActivity[CatalystActivity:9984972] histone H3K27me2/H3K27me3 demethylase activity of ORF50 gene:H3K4me3,H3K27me3-Nucleosome:SIRT1:PAN RNA:KDM6A,B [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9984987] Stephan, Ralf, 2026-03-13
crossReference[DatabaseIdentifier:9985018] RHEA:60225
input[Complex:9984953] ORF50 gene:H3K4me3,H3K27me3-Nucleosome:SIRT1:PAN RNA [nucleoplasm] [Homo sapiens]
[SimpleEntity:113685] O2 [nucleoplasm]
[SimpleEntity:113685] O2 [nucleoplasm]
[SimpleEntity:113671] 2OG [nucleoplasm]
[SimpleEntity:113671] 2OG [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:9985002] KSHV PAN RNA associates with demethylases UTX and JMJD3 to activate lytic replication through a physical interaction with the virus genome
[LiteratureReference:9984955] Reactivation and Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus: An Update
[LiteratureReference:4687075] UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
modified[InstanceEdit:9985631] Stephan, Ralf, 2026-03-23
nameKDM6A,B demethylates H3K27
output[Complex:9985010] ORF50 gene:H3K4me3,H3K27me1-Nucleosome:SIRT1:PAN RNA [nucleoplasm] [Homo sapiens]
[SimpleEntity:159942] CO2 [nucleoplasm]
[SimpleEntity:159942] CO2 [nucleoplasm]
[SimpleEntity:29478] CH2O [nucleoplasm]
[SimpleEntity:29478] CH2O [nucleoplasm]
[SimpleEntity:159939] SUCCA [nucleoplasm]
[SimpleEntity:159939] SUCCA [nucleoplasm]
precedingEvent
relatedSpecies[Species:2671781] Human herpesvirus 8
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9985039] R-HSA-9984982.1
summation[Summation:9985027] KDM6-family histone demethylases KDM6A (UTX) and/or KDM6B (J...
(hasEvent)[Pathway:9976097] Establishment of Lytic HHV8 Infection [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9984996] H3K27me1 is removed from H3 [Homo sapiens]
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No pathways have been reviewed or authored by KDM6A,B demethylates H3K27 (9984982)