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Details on Person Activated RPS6KA5 phosphorylates H3K27me3

Class:Id	Reaction:9984401
_displayName	Activated RPS6KA5 phosphorylates H3K27me3
_doRelease	FALSE
_timestamp	2026-03-23 08:53:56
authored	[InstanceEdit:9984417] Stephan, Ralf, 2026-03-06
catalystActivity	[CatalystActivity:199934] protein serine/threonine kinase activity of p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984429] Stephan, Ralf, 2026-03-07
crossReference	[DatabaseIdentifier:9857128] RHEA:17990
disease	[Disease:3134794] viral infectious disease
goBiologicalProcess	[GO_BiologicalProcess:3600] peptidyl-serine phosphorylation
input	[SimpleEntity:29358] ATP [nucleoplasm] [Complex:9984953] ORF50 gene:H3K4me3,H3K27me3-Nucleosome:SIRT1:PAN RNA [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9984413] Oxidative stress induces reactivation of Kaposi's sarcoma-associated herpesvirus and death of primary effusion lymphoma cells [LiteratureReference:9984393] Histone code pathway involving H3 S28 phosphorylation and K27 acetylation activates transcription and antagonizes polycomb silencing [LiteratureReference:9984371] MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14
modified	[InstanceEdit:9984987] Stephan, Ralf, 2026-03-13 [InstanceEdit:9985631] Stephan, Ralf, 2026-03-23
name	Activated RPS6KA5 phosphorylates H3K27me3
output	[SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:9668967] H+ [nucleoplasm] [Complex:9984372] ORF50 gene:H3K4me3,H3K27me3S28ph-Nucleosome:SIRT1:PAN RNA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9984965] PAN RNA binds to ORF50 promoter [Homo sapiens]
relatedSpecies	[Species:2671781] Human herpesvirus 8
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9984444] R-HSA-9984401.1
structureModified	[InstanceEdit:9984987] Stephan, Ralf, 2026-03-13
summation	[Summation:9984408] Oxidative stress and, in general, disturbance of the redox b...
(hasEvent)	[Pathway:9976097] Establishment of Lytic HHV8 Infection [Homo sapiens]
(precedingEvent)	[Reaction:9984378] Dissociation of PRC2 from episome [Homo sapiens] [BlackBoxEvent:9984494] Replication-coupled erasure of H3K27me3,S28ph [Homo sapiens]
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