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Details on Person Dissociation of PRC2 from episome

Class:Id	Reaction:9984378
_displayName	Dissociation of PRC2 from episome
_doRelease	FALSE
_timestamp	2026-03-23 08:54:14
authored	[InstanceEdit:9984417] Stephan, Ralf, 2026-03-06
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984429] Stephan, Ralf, 2026-03-07
disease	[Disease:3134794] viral infectious disease
input	[Complex:9983760] PRC2 complex:Me-R20-LANA1 Oligomer:HHV8 Circular Episome:Condensed prophase chromosome [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9983762] Epigenetic analysis of KSHV latent and lytic genomes [LiteratureReference:9983759] ZIC2 Is Essential for Maintenance of Latency and Is a Target of an Immediate Early Protein during Kaposi's Sarcoma-Associated Herpesvirus Lytic Reactivation [LiteratureReference:9984393] Histone code pathway involving H3 S28 phosphorylation and K27 acetylation activates transcription and antagonizes polycomb silencing
modified	[InstanceEdit:9985631] Stephan, Ralf, 2026-03-23
name	Dissociation of PRC2 from episome
output	[Complex:9981981] Me-R20-LANA1 Oligomer:HHV8 Circular Episome:Condensed prophase chromosome [nucleoplasm] [Homo sapiens] [Complex:212285] PRC2 (EZH2) Core [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9984401] Activated RPS6KA5 phosphorylates H3K27me3 [Homo sapiens] [Reaction:9984965] PAN RNA binds to ORF50 promoter [Homo sapiens] [BlackBoxEvent:9984375] ORF50 ubiquitinates ZIC2 [Homo sapiens] [BlackBoxEvent:9985134] ORF50 and ITCH ubiquitinate ORF71 [Homo sapiens] [BlackBoxEvent:9985508] ORF50 ubiquitinates ZNF426 [Homo sapiens]
regulatedBy	[PositiveRegulation:9984394] Positive regulation by 'ORF50 gene:H3K4me3,H3K27me3S28ph-Nucleosome:SIRT1:PAN RNA [nucleoplasm]' [PositiveRegulation:9984398] Positive regulation by 'K48polyUb-ZIC2 [nucleoplasm]'
relatedSpecies	[Species:2671781] Human herpesvirus 8
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9984438] R-HSA-9984378.1
summation	[Summation:9984426] RTA-mediated reactivation induces PRC2 dissociation from the...
(hasEvent)	[Pathway:9976097] Establishment of Lytic HHV8 Infection [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9984494] Replication-coupled erasure of H3K27me3,S28ph [Homo sapiens] [Reaction:9985150] PAN RNA binds to LANA1 [Homo sapiens] [Reaction:9985155] LANA1 dissociates from episome [Homo sapiens]
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No pathways have been reviewed or authored by Dissociation of PRC2 from episome (9984378)