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Details on Person ORF50 ubiquitinates ZIC2

Class:IdBlackBoxEvent:9984375
_displayNameORF50 ubiquitinates ZIC2
_doReleaseFALSE
_timestamp2026-03-23 08:56:27
authored[InstanceEdit:9984417] Stephan, Ralf, 2026-03-06
catalystActivity[CatalystActivity:9984422] ubiquitin protein ligase activity of p-ORF50 tetramer [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9984429] Stephan, Ralf, 2026-03-07
disease[Disease:3134794] viral infectious disease
goBiologicalProcess[GO_BiologicalProcess:447938] protein K48-linked ubiquitination
input[EntityWithAccessionedSequence:5216208] ZIC2 [nucleoplasm] [Homo sapiens]
[Polymer:5683044] K48polyUb [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9976835] The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradation
[LiteratureReference:9983762] Epigenetic analysis of KSHV latent and lytic genomes
[LiteratureReference:9983759] ZIC2 Is Essential for Maintenance of Latency and Is a Target of an Immediate Early Protein during Kaposi's Sarcoma-Associated Herpesvirus Lytic Reactivation
modified[InstanceEdit:9985220] Stephan, Ralf, 2026-03-17
[InstanceEdit:9985631] Stephan, Ralf, 2026-03-23
nameORF50 ubiquitinates ZIC2
output[EntityWithAccessionedSequence:9984406] K48polyUb-ZIC2 [nucleoplasm] [Homo sapiens]
precedingEvent
relatedSpecies[Species:2671781] Human herpesvirus 8
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9984439] R-HSA-9984375.1
structureModified[InstanceEdit:9985220] Stephan, Ralf, 2026-03-17
summation[Summation:9984381] HHV8 Replication and transcription activator (ORF50, RTA) ub...
(hasEvent)[Pathway:9976097] Establishment of Lytic HHV8 Infection [Homo sapiens]
(precedingEvent)[Reaction:9984378] Dissociation of PRC2 from episome [Homo sapiens]
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No pathways have been reviewed or authored by ORF50 ubiquitinates ZIC2 (9984375)