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Details on Person SET1A complex methylates histone H3 on ORF50 promoter

Class:Id	Reaction:9983744
_displayName	SET1A complex methylates histone H3 on ORF50 promoter
_doRelease	FALSE
_timestamp	2026-03-23 08:57:50
authored	[InstanceEdit:9983738] Stephan, Ralf, 2026-02-27
catalystActivity	[CatalystActivity:9983745] histone H3K4 methyltransferase activity of SET1A complex:Me-R20-LANA1 Oligomer:HHV8 Circular Episome:Condensed prophase chromosome [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9983746] Stephan, Ralf, 2026-02-27
crossReference	[DatabaseIdentifier:9983739] RHEA:60265 [DatabaseIdentifier:9983786] RHEA:60269 [DatabaseIdentifier:9983777] RHEA:60273
disease	[Disease:3134794] viral infectious disease
goBiologicalProcess	[GO_BiologicalProcess:2298] peptidyl-lysine trimethylation
input	[SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [Complex:9983660] ORF50 gene:Nucleosome:SIRT1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9983693] LANA binds to multiple active viral and cellular promoters and associates with the H3K4methyltransferase hSET1 complex [LiteratureReference:9983740] The epigenetic landscape of latent Kaposi sarcoma-associated herpesvirus genomes
modified	[InstanceEdit:9983778] Stephan, Ralf, 2026-02-27 [InstanceEdit:9984280] Orlic-Milacic, Marija, 2026-03-06 [InstanceEdit:9985631] Stephan, Ralf, 2026-03-23
name	SET1A complex methylates histone H3 on ORF50 promoter
output	[Complex:9983742] ORF50 gene:H3K4me3-Nucleosome:SIRT1 [nucleoplasm] [Homo sapiens] [SimpleEntity:9668967] H+ [nucleoplasm] [SimpleEntity:9668967] H+ [nucleoplasm] [SimpleEntity:9668967] H+ [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:9983687] LANA1 recruits the SET1A complex [Homo sapiens] [Reaction:9973876] LANA1 tethers HHV8 circular dsDNA to host chromosomes [Homo sapiens] [Reaction:9983406] SIRT1 binds to ORF50 promoter [Homo sapiens] [Reaction:9973876] LANA1 tethers HHV8 circular dsDNA to host chromosomes [Homo sapiens]
relatedSpecies	[Species:2671781] Human herpesvirus 8
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9983748] R-HSA-9983744.1
summation	[Summation:9983741] Histone-lysine N-methyltransferase complex SET1A methylates ...
(hasEvent)	[Pathway:9983305] Establishment of Latent HHV8 Infection [Homo sapiens]
(precedingEvent)	[Reaction:9983784] PRC2 complex methylates histone H3 on ORF50 promoter [Homo sapiens]
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