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Details on Person SIRT1 binds to ORF50 promoter

Class:IdReaction:9983406
_displayNameSIRT1 binds to ORF50 promoter
_doReleaseFALSE
_timestamp2026-03-06 11:51:11
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9983392] Stephan, Ralf, 2026-02-23
disease[Disease:3134794] viral infectious disease
goBiologicalProcess[GO_BiologicalProcess:17801] negative regulation of DNA-templated transcription
input[EntityWithAccessionedSequence:427531] SIRT1 [nucleoplasm] [Homo sapiens]
[Complex:9983657] ORF50 gene:Nucleosome [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9983383] Short-chain fatty acids from periodontal pathogens suppress histone deacetylases, EZH2, and SUV39H1 to promote Kaposi's sarcoma-associated herpesvirus replication
[LiteratureReference:9983386] Activation of Kaposi's sarcoma-associated herpesvirus (KSHV) by inhibitors of class III histone deacetylases: identification of sirtuin 1 as a regulator of the KSHV life cycle
[LiteratureReference:9983403] A novel role of SIRT1 in gammaherpesvirus latency and replication
modified[InstanceEdit:9983659] Stephan, Ralf, 2026-02-26
[InstanceEdit:9983688] Stephan, Ralf, 2026-02-26
[InstanceEdit:9983738] Stephan, Ralf, 2026-02-27
[InstanceEdit:9984280] Orlic-Milacic, Marija, 2026-03-06
nameSIRT1 binds to ORF50 promoter
output[Complex:9983660] ORF50 gene:Nucleosome:SIRT1 [nucleoplasm] [Homo sapiens]
precedingEvent
relatedSpecies[Species:2671781] Human herpesvirus 8
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9983408] R-HSA-9983406.1
structureModified[InstanceEdit:9983659] Stephan, Ralf, 2026-02-26
summation[Summation:9983393] NAD-dependent protein deacetylase Sirtuin-1 (SIRT1) binds to...
(hasEvent)[Pathway:9983305] Establishment of Latent HHV8 Infection [Homo sapiens]
(precedingEvent)[Reaction:9983744] SET1A complex methylates histone H3 on ORF50 promoter [Homo sapiens]
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