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Details on Person Unknown:P58390-2 Kcnn2
| Class:Id | ReferenceIsoform:9983192 |
|---|---|
| _chainChangeLog | chain:1-574 for 9983192 added on Fri Feb 20 2026 |
| _displayName | Unknown:P58390-2 Kcnn2 |
| _timestamp | 2026-02-20 23:20:12 |
| chain | chain:1-574 |
| checksum | 259CB8CDE4D1CDE6 |
| comment | FUNCTION Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:11557517, PubMed:13679367, PubMed:14657188). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (PubMed:14657188). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (PubMed:13679367). The inward rectification could be due to a blockade of the outward current by intracellular divalent cations such as calcium and magnesium and could also be due to an intrinsic property of the channel pore, independent of intracellular divalent ions. There are three positively charged amino acids in the S6 transmembrane domain, close to the pore, that collectively control the conductance and rectification through an electrostatic mechanism. Additionally, electrostatic contributions from these residues also play an important role in determining the intrinsic open probability of the channel in the absence of calcium, affecting the apparent calcium affinity for activation. Forms an heteromeric complex with calmodulin, which is constitutively associated in a calcium-independent manner. Channel opening is triggered when calcium binds the calmodulin resulting in a rotary movement leading to the formation of the dimeric complex to open the gate (By similarity). Plays a role in the repolarization phase of cardiac action potential (By similarity).CATALYTIC ACTIVITY K(+)(in) = K(+)(out)ACTIVITY REGULATION Inhibited by bee venom neurotoxin apamin (PubMed:11557517, PubMed:13679367, PubMed:14657188). Inhibited by UCL 1684 and tetraethylammonium (TEA) (By similarity).SUBUNIT Homodimer (PubMed:20689065). Heteromultimer with KCNN1 and KCNN3 (PubMed:20689065). The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity). Interacts (via N-terminal domain) with MPP2 (PubMed:26880549).SUBCELLULAR LOCATION Expressed in atrial and ventricular myocytes with higher levels in atrial myocytes (at protein level) (PubMed:13679367, PubMed:16055520, PubMed:20689065). Highly expressed in brain, liver and colon with low levels in kidney and testis (PubMed:11557517). In colon, detected in smooth muscle cells (PubMed:11557517).TISSUE SPECIFICITY Widely expressed, with highest levels in the brain (hippocampus, cortex, cerebellum, olfactory lobes). Also expressed in other tissues, such as trachea, kidney, stomach, testis, bone marrow and prostate.TISSUE SPECIFICITY Expressed at high levels in olfactory lobes and heart and at lower levels, in the hippocampus, cortex, cerebellum, retina, lung, liver and skeletal muscle. Expressed at lower levels than isoform 1.INDUCTION Up-regulated by TNF in brain cortical cells. This induction can be further increased by the addition of glutamate.DOMAIN The calmodulin-binding domain (CaMBD) forms an elongated dimer with a calmodulin molecule bound at each end; each calmodulin wraps around three alpha-helices, two from one CaMBD subunit and one from the other.DOMAIN The coiled-coil domaim mediates heteromeic assembly.SIMILARITY Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| description | recommendedName: fullName evidence="14"Small conductance calcium-activated potassium channel protein 2 shortName evidence="13"SK2 shortName: SKCa 2 shortName: SKCa2 alternativeName: KCa2.2 |
| geneName | Kcnn2 Sk2 |
| identifier | P58390 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Calmodulin-binding Cell membrane Cytoplasm Ion channel Ion transport Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport |
| name | Kcnn2 |
| secondaryIdentifier | KCNN2_MOUSE A0A1B0GT12 B4YDY0 E9QNY5 Q3UF29 Q540U9 Q8CCH4 |
| sequenceLength | 574 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | P58390-2 |
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No pathways have been reviewed or authored by Unknown:P58390-2 Kcnn2 (9983192)
