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Details on Person Sirt1 binds Ac-13K-Ppargc1a:Rora:Bmal1

Class:IdReaction:9982776
_displayNameSirt1 binds Ac-13K-Ppargc1a:Rora:Bmal1
_timestamp2026-03-23 17:44:24
authored[InstanceEdit:9982780] May, Bruce, 2026-02-19
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9982777] May, Bruce, 2026-02-19
edited[InstanceEdit:9982780] May, Bruce, 2026-02-19
input[EntityWithAccessionedSequence:5211238] Sirt1 [nucleoplasm] [Mus musculus]
[Complex:9982781] Ac-13K-Ppargc1a:Rora:Bmal1 gene [nucleoplasm] [Mus musculus]
internalReviewed[InstanceEdit:9985656] Gillespie, Marc E, 2026-03-23
isChimericFALSE
literatureReference[LiteratureReference:3270608] Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
[LiteratureReference:9961180] SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}
[LiteratureReference:5656523] SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging
[LiteratureReference:1368121] Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism
modified[InstanceEdit:9985658] May, Bruce, 2026-03-23
nameSirt1 binds Ac-13K-Ppargc1a:Rora:Bmal1
output[Complex:9960051] Ac-13K-Ppargc1a:Sirt1:Rora:Bmal1 gene [nucleoplasm] [Mus musculus]
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48892] Mus musculus
stableIdentifier[StableIdentifier:9982785] R-MMU-9982776.1
summation[Summation:9982784] Fasting induces expression of Sirt1, which interacts with Pp...
(inferredFrom)[Reaction:9961791] SIRT1 binds Ac-13K-PPARGC1A:RORA:BMAL1 gene [Homo sapiens]
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