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Details on Person DNAAF1 binds CFAP298

Class:Id	Reaction:9982764
_displayName	DNAAF1 binds CFAP298
_timestamp	2026-02-18 21:23:53
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9982765] Rothfels, Karen, 2026-02-18
inferredFrom	[Reaction:9982766] dnaaf1 binds cfap298 [Danio rerio]
input	[EntityWithAccessionedSequence:9970775] DNAAF1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9982728] CFAP298 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[Book:9969494] Desai, PB Cytoplasmic preassembly and trafficking of axonemal dyneins Dyneins Structure Biology and Disease in "Dyneins Structure Biology and Disease" [LiteratureReference:9975954] LRRC50, a conserved ciliary protein implicated in polycystic kidney disease [LiteratureReference:9975946] Deletions and point mutations of LRRC50 cause primary ciliary dyskinesia due to dynein arm defects [LiteratureReference:9975957] Loss-of-function mutations in the human ortholog of Chlamydomonas reinhardtii ODA7 disrupt dynein arm assembly and cause primary ciliary dyskinesia [LiteratureReference:9970758] DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport [LiteratureReference:9982699] c21orf59/kurly Controls Both Cilia Motility and Polarization [LiteratureReference:9981280] Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia
name	DNAAF1 binds CFAP298
output	[Complex:9982733] DNAAF1:CFAP298 [cytosol] [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9982768] R-HSA-9982764.1
summation	[Summation:9982742] DNAAF1 (also known as LRRC50) is a cytoplasmic protein requi...
(hasEvent)	[Pathway:9969543] Assembly of the epithelial motile axoneme [Homo sapiens]
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No pathways have been reviewed or authored by DNAAF1 binds CFAP298 (9982764)