Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person K5 binds to PLP2

Class:IdReaction:9982307
_displayNameK5 binds to PLP2
_doReleaseFALSE
_timestamp2026-06-04 16:58:00
authored[InstanceEdit:9982301] Stephan, Ralf, 2026-02-16
compartment[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:9982309] Stephan, Ralf, 2026-02-16
disease[Disease:3134794] viral infectious disease
input[EntityWithAccessionedSequence:5216106] PLP2 [endoplasmic reticulum membrane] [Homo sapiens]
[EntityWithAccessionedSequence:9973292] K5 [endoplasmic reticulum membrane] [Human herpesvirus 8]
internalReviewed[InstanceEdit:9985769] Orlic-Milacic, Marija, 2026-03-26
isChimericFALSE
literatureReference[LiteratureReference:9978849] Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases
modified[InstanceEdit:9983303] Stephan, Ralf, 2026-02-21
[InstanceEdit:9985311] Stephan, Ralf, 2026-03-18
[InstanceEdit:9985776] Stephan, Ralf, 2026-03-26
[InstanceEdit:9991264] Stephan, Ralf, 2026-06-04
nameK5 binds to PLP2
output[Complex:9982308] K5:PLP2 [endoplasmic reticulum membrane] [Homo sapiens]
relatedSpecies[Species:2671781] Human herpesvirus 8
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9982311] R-HSA-9982307.1
summation[Summation:9982310] HHV8 E3 ubiquitin-protein ligase K5 (aka MIR2 or ORFK5) bind...
(hasEvent)[Pathway:9976073] Maturation/Activation of Immediate/Early HHV8 Proteins [Homo sapiens]
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