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Details on Person vPK phosphorylates ORF59 dimer in RC

Class:IdReaction:9982130
_displayNamevPK phosphorylates ORF59 dimer in RC
_doReleaseFALSE
_timestamp2026-05-15 08:53:52
authored[InstanceEdit:9982115] Stephan, Ralf, 2026-02-13
catalystActivity[CatalystActivity:9978806] protein serine/threonine kinase activity of p-S-vPK [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9982131] Stephan, Ralf, 2026-02-14
crossReference[DatabaseIdentifier:9857128] RHEA:17990
disease[Disease:3134794] viral infectious disease
goBiologicalProcess[GO_BiologicalProcess:3601] protein phosphorylation
input[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[Complex:9981633] Replication complex [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9985769] Orlic-Milacic, Marija, 2026-03-26
isChimericFALSE
literatureReference[LiteratureReference:9979037] Phosphorylation of Kaposi's sarcoma-associated herpesvirus processivity factor ORF59 by a viral kinase modulates its ability to associate with RTA and oriLyt
[LiteratureReference:9982116] Interaction of Kaposi's sarcoma-associated herpesvirus ORF59 with oriLyt is dependent on binding with K-Rta
modified[InstanceEdit:9983303] Stephan, Ralf, 2026-02-21
[InstanceEdit:9985311] Stephan, Ralf, 2026-03-18
[InstanceEdit:9985778] Stephan, Ralf, 2026-03-26
[InstanceEdit:9989144] Stephan, Ralf, 2026-05-15
namevPK phosphorylates ORF59 dimer in RC
output[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[Complex:9982132] p-Replication complex [nucleoplasm] [Human herpesvirus 8]
precedingEvent
relatedSpecies[Species:2671781] Human herpesvirus 8
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9982135] R-HSA-9982130.1
summation[Summation:9982134] HHV8 Viral protein kinase (vPK, ORF36) phosphorylates HHV8 D...
(hasEvent)[Pathway:9976070] Maturation/Activation of Late HHV8 Lytic Proteins [Homo sapiens]
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No pathways have been reviewed or authored by vPK phosphorylates ORF59 dimer in RC (9982130)
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