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Details on Person DLL4 acting via NOTCH1 enhances expression of HES1 in human ...
| Class:Id | Summation:9981848 |
|---|---|
| _displayName | DLL4 acting via NOTCH1 enhances expression of HES1 in human ... |
| _timestamp | 2026-02-16 18:48:31 |
| created | [InstanceEdit:9981870] May, Bruce, 2026-02-11 |
| literatureReference | [LiteratureReference:9981840] Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades |
| modified | [InstanceEdit:9982319] May, Bruce, 2026-02-16 |
| text | DLL4 acting via NOTCH1 enhances expression of HES1 in human umbilical vessel endothelial cells (Harrington et al. 2008). DLL4 from endothelial tip cells binds NOTCH1 on endothelial stalk cells and causes NOTCH1 to be cleaved, yielding the NOTCH1 intracellular domain (NICD1) that binds RBPJ at the HES1 promoter (inferred from mouse Nicd1 and human RBPJ in Jarriault et al. 1995) and enhances expression in endothelial stalk cells (inferred from mouse cells in Moya et al. 2012). |
| (summation) | [BlackBoxEvent:9979299] NICD1:RBPJ positively regulates expression of HES1 [Homo sapiens] |
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No pathways have been reviewed or authored by DLL4 acting via NOTCH1 enhances expression of HES1 in human ... (9981848)
