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Details on Person DLL4 (tip cell) binds Fringe-modified-NOTCH1 (stalk cell)

Class:Id	Reaction:9980951
_displayName	DLL4 (tip cell) binds Fringe-modified-NOTCH1 (stalk cell)
_timestamp	2026-03-18 16:42:09
authored	[InstanceEdit:9980952] May, Bruce, 2026-01-31
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9980923] May, Bruce, 2026-02-04
edited	[InstanceEdit:9980952] May, Bruce, 2026-01-31
inferredFrom	[Reaction:9981342] Dll4 (tip cell) binds Fringe-modified Notch1 (stalk cell) [Mus musculus]
input	[EntityWithAccessionedSequence:158437] DLL4 [plasma membrane] [Homo sapiens] [Complex:1911516] Fringe-modified NOTCH1 [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9985318] D'Eustachio, Peter, 2026-03-18
isChimeric	FALSE
modified	[InstanceEdit:9981222] May, Bruce, 2026-02-06 [InstanceEdit:9981355] May, Bruce, 2026-02-07 [InstanceEdit:9985321] May, Bruce, 2026-03-18
name	DLL4 (tip cell) binds Fringe-modified-NOTCH1 (stalk cell)
output	[Complex:9980910] DLL4:Fringe-modified NOTCH1 [plasma membrane] [Homo sapiens]
participantCellType	[PhysicalEntityCellType:9979136] DLL4 [plasma membrane] in endothelial tip cell [PhysicalEntityCellType:9980965] Fringe-modified NOTCH1 [plasma membrane] in endothelial stalk cell
precedingEvent	[BlackBoxEvent:9917438] Expression of DLL4 is positively regulated by VEGFA, MEF2A,C,D, and ERG in endothelial tip cell [Homo sapiens] [Reaction:9917477] MEF2A,C,D:HDAC4,7,9:DLL4 gene releases HDAC4,7,9 and binds EP300 and ERG [Homo sapiens] [Reaction:5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9980977] R-HSA-9980951.1
summation	[Summation:9981216] DLL4 on an endothelial tip cell binds NOTCH1 on adjacent sta...
(hasEvent)	[Pathway:9917416] Sprouting angiogenesis [Homo sapiens]
(precedingEvent)	[Reaction:9980902] Mind bomb 1 (MIB1) ubiquitinates DLL4 in DLL4:NOTCH1 [Homo sapiens]
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No pathways have been reviewed or authored by DLL4 (tip cell) binds Fringe-modified-NOTCH1 (stalk cell) (9980951)