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Details on Person ADAM10 cleaves NOTCH1

Class:IdReaction:9980928
_displayNameADAM10 cleaves NOTCH1
_timestamp2026-03-18 16:42:06
authored[InstanceEdit:9980952] May, Bruce, 2026-01-31
catalystActivity[CatalystActivity:157208] metallopeptidase activity of ADAM10:Zn2+ [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9980923] May, Bruce, 2026-02-04
edited[InstanceEdit:9980952] May, Bruce, 2026-01-31
inferredFrom
input[Complex:9980950] Ub-DLL4:NOTCH1 [plasma membrane] [Homo sapiens]
internalReviewed[InstanceEdit:9985318] D'Eustachio, Peter, 2026-03-18
isChimericFALSE
modified[InstanceEdit:9981618] May, Bruce, 2026-02-10
[InstanceEdit:9985321] May, Bruce, 2026-03-18
nameADAM10 cleaves NOTCH1
output[EntityWithAccessionedSequence:157200] NEXT1 [plasma membrane] [Homo sapiens]
[Complex:9980948] Ub-DLL4:Fringe-modified NOTCH1 fragment [plasma membrane] [Homo sapiens]
participantCellType[PhysicalEntityCellType:9980905] NEXT1 [plasma membrane] in endothelial stalk cell
[PhysicalEntityCellType:9981605] ADAM10:Zn2+ [plasma membrane] in endothelial stalk cell
precedingEvent
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9980972] R-HSA-9980928.1
structureModified[InstanceEdit:9981618] May, Bruce, 2026-02-10
summation[Summation:9981606] In response to a ligand such as DLL4 binding to NOTCH1, ADAM...
(hasEvent)[Pathway:9917416] Sprouting angiogenesis [Homo sapiens]
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No pathways have been reviewed or authored by ADAM10 cleaves NOTCH1 (9980928)