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Details on Person Gamma-secretase cleaves NEXT1 yielding NICD1

Class:Id	Reaction:9980918
_displayName	Gamma-secretase cleaves NEXT1 yielding NICD1
_timestamp	2026-03-18 16:42:30
authored	[InstanceEdit:9980923] May, Bruce, 2026-02-04
catalystActivity	[CatalystActivity:157355] aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9980923] May, Bruce, 2026-02-04
edited	[InstanceEdit:9980923] May, Bruce, 2026-02-04
inferredFrom	[Reaction:209285] The transmembrane complex Murine gamma-secretase cleaves Murine NEXT at the S3 site leaving NTM and releasing NICD into the cytoplasm [Mus musculus]
input	[EntityWithAccessionedSequence:157200] NEXT1 [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9985318] D'Eustachio, Peter, 2026-03-18
literatureReference	[LiteratureReference:157796] Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling [LiteratureReference:163904] A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain [LiteratureReference:163911] Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain [LiteratureReference:163903] Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1 [LiteratureReference:2157466] The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer
modified	[InstanceEdit:9981618] May, Bruce, 2026-02-10 [InstanceEdit:9982246] May, Bruce, 2026-02-14 [InstanceEdit:9985321] May, Bruce, 2026-03-18
name	Gamma-secretase cleaves NEXT1 yielding NICD1
output	[EntityWithAccessionedSequence:157634] NICD1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:157656] NOTCH1(1721-1753) [plasma membrane] [Homo sapiens]
participantCellType	[PhysicalEntityCellType:9980905] NEXT1 [plasma membrane] in endothelial stalk cell [PhysicalEntityCellType:9980895] NICD1 [cytosol] in endothelial stalk cell [PhysicalEntityCellType:9980888] gamma-secretase complex [plasma membrane] in endothelial stalk cell
precedingEvent	[Reaction:157632] Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 [Homo sapiens] [Reaction:1980074] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 [Homo sapiens]
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9980973] R-HSA-9980918.1
summation	[Summation:9981617] The Notch Extracellular Truncation 1 (NEXT1) fragment of NOT...
(hasEvent)	[Pathway:9917416] Sprouting angiogenesis [Homo sapiens]
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No pathways have been reviewed or authored by Gamma-secretase cleaves NEXT1 yielding NICD1 (9980918)