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Details on Person Mind bomb 1 (MIB1) ubiquitinates DLL4 in DLL4:NOTCH1

Class:Id	Reaction:9980902
_displayName	Mind bomb 1 (MIB1) ubiquitinates DLL4 in DLL4:NOTCH1
_timestamp	2026-03-18 16:42:46
authored	[InstanceEdit:9980952] May, Bruce, 2026-01-31
catalystActivity	[CatalystActivity:9980897] ubiquitin protein ligase activity of MIB1 [cytosol]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9980923] May, Bruce, 2026-02-04
edited	[InstanceEdit:9980952] May, Bruce, 2026-01-31
inferredFrom	[Reaction:209226] DL/SER is ubiquitinated by E3 ubiquitination ligases (NEUR/MIB1) [Drosophila melanogaster]
input	[Complex:9980910] DLL4:Fringe-modified NOTCH1 [plasma membrane] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9985318] D'Eustachio, Peter, 2026-03-18
isChimeric	FALSE
modified	[InstanceEdit:9981222] May, Bruce, 2026-02-06 [InstanceEdit:9981372] May, Bruce, 2026-02-07 [InstanceEdit:9985321] May, Bruce, 2026-03-18
name	Mind bomb 1 (MIB1) ubiquitinates DLL4 in DLL4:NOTCH1
output	[Complex:9980950] Ub-DLL4:NOTCH1 [plasma membrane] [Homo sapiens]
participantCellType	[PhysicalEntityCellType:9979136] DLL4 [plasma membrane] in endothelial tip cell [PhysicalEntityCellType:9980965] Fringe-modified NOTCH1 [plasma membrane] in endothelial stalk cell [PhysicalEntityCellType:9980887] MIB1 [cytosol] in endothelial tip cell
precedingEvent	[Reaction:9980951] DLL4 (tip cell) binds Fringe-modified-NOTCH1 (stalk cell) [Homo sapiens] [BlackBoxEvent:9917438] Expression of DLL4 is positively regulated by VEGFA, MEF2A,C,D, and ERG in endothelial tip cell [Homo sapiens]
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9980982] R-HSA-9980902.1
structureModified	[InstanceEdit:9981222] May, Bruce, 2026-02-06
summation	[Summation:9980967] Mind Bomb 1 (MIB1) interacts with and ubiquitinates the intr...
(hasEvent)	[Pathway:9917416] Sprouting angiogenesis [Homo sapiens]
(precedingEvent)	[Reaction:9980928] ADAM10 cleaves NOTCH1 [Homo sapiens]
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No pathways have been reviewed or authored by Mind bomb 1 (MIB1) ubiquitinates DLL4 in DLL4:NOTCH1 (9980902)