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Details on Person Three HHV8 (KSHV) genes are transcribed from the LANA promot...
| Class:Id | Summation:9980832 |
|---|---|
| _displayName | Three HHV8 (KSHV) genes are transcribed from the LANA promot... |
| _timestamp | 2026-04-23 18:11:28 |
| created | [InstanceEdit:9980828] Orlic-Milacic, Marija, 2026-02-03 |
| literatureReference | [LiteratureReference:9980820] Transcriptional analysis of human herpesvirus-8 open reading frames 71, 72, 73, K14, and 74 in a primary effusion lymphoma cell line [LiteratureReference:9980819] A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirus [LiteratureReference:9980840] Viral miRNA targeting of bicistronic and polycistronic transcripts [LiteratureReference:9980843] Piracy of prostaglandin E2/EP receptor-mediated signaling by Kaposi's sarcoma-associated herpes virus (HHV-8) for latency gene expression: strategy of a successful pathogen [LiteratureReference:9980877] Characterization and cell cycle regulation of the major Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) latent genes and their promoter |
| modified | [InstanceEdit:9980841] Orlic-Milacic, Marija, 2026-02-03 [InstanceEdit:9980846] Orlic-Milacic, Marija, 2026-02-03 [InstanceEdit:9980878] Orlic-Milacic, Marija, 2026-02-03 [InstanceEdit:9987662] Stephan, Ralf, 2026-04-23 |
| text | Three HHV8 (KSHV) genes are transcribed from the LANA promoter as a polycistronic pre-mRNA: ORF73 (encoding LANA1), ORF72 (encoding vCyclin) and ORF71 (encoding vFLIP) (Dittmer et al. 1998; Talbot et al. 1999; Sarid et al. 1999). Transcription of these genes is essential for the establishment of latent infection, but they are also transcribed during lytic infection, with activating transcription factors differing between latent and lytic stages of the HHV8 life cycle (Dittmer et al. 1998; Talbot et al. 1999; Sarid et al. 1999). Introns separating ORF73, ORF72 and ORF71 portions of the polycistronic pre-mRNA are subsequently alternatively spliced, producing several mature transcripts with overlapping 3' ends that are either tricistronic or bicistronic (Dittmer et al. 1998; Talbot et al. 1999; Sarid et al. 1999). HHV8-encoded microRNA, miR-K10, negatively regulates translation of all transcripts derived from the polycistronic ORF73-ORF72-ORF71 pre-mRNA (reviewed in Zhu et al. 2014). Prostaglandin E2 (PGE2) positively regulates transcription from the LANA promoter and the establishment of latent infection (George Paul et al. 2010). |
| (summation) | [BlackBoxEvent:9973887] Transcription of polycistronic ORF73-ORF72-ORF71 pre-mRNA [Homo sapiens] |
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No pathways have been reviewed or authored by Three HHV8 (KSHV) genes are transcribed from the LANA promot... (9980832)
