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Details on Person pre-ORF17 forms dimer inside procapsid

Class:Id	Reaction:9980770
_displayName	pre-ORF17 forms dimer inside procapsid
_doRelease	FALSE
_timestamp	2026-06-05 07:09:42
authored	[InstanceEdit:9980729] Stephan, Ralf, 2026-02-02
compartment	[Compartment:830] viral capsid
created	[InstanceEdit:9980782] Stephan, Ralf, 2026-02-03
disease	[Disease:3134794] viral infectious disease
goBiologicalProcess	[GO_BiologicalProcess:160867] protein homooligomerization
input	[Complex:9991207] Procapsid:1200xSCAF:300xORF17 [viral capsid] [Human herpesvirus 8]
internalReviewed	[InstanceEdit:9985769] Orlic-Milacic, Marija, 2026-03-26
isChimeric	FALSE
literatureReference	[LiteratureReference:9980773] The effect of dimerization and ligand binding on the dynamics of Kaposi's sarcoma-associated herpesvirus protease [LiteratureReference:9980787] One functional switch mediates reversible and irreversible inactivation of a herpesvirus protease [LiteratureReference:9980778] Conformational change coupling the dimerization and activation of KSHV protease [LiteratureReference:9980776] Kaposi's sarcoma-associated herpesvirus ORF17 plays a key role in capsid maturation [LiteratureReference:9991266] The protease and the assembly protein of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8)
modified	[InstanceEdit:9983303] Stephan, Ralf, 2026-02-21 [InstanceEdit:9985311] Stephan, Ralf, 2026-03-18 [InstanceEdit:9985778] Stephan, Ralf, 2026-03-26 [InstanceEdit:9991595] Stephan, Ralf, 2026-06-05
name	pre-ORF17 forms dimer inside procapsid
output	[Complex:9986383] Procapsid:1200xSCAF:150xORF17 dimer [viral capsid] [Human herpesvirus 8]
precedingEvent	[BlackBoxEvent:9986387] pre-ORF17 and SCAF enter Procapsid [Homo sapiens] [BlackBoxEvent:9986261] Procapsid assembles [Homo sapiens] [BlackBoxEvent:9980774] pre-ORF17 moves to nucleus [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
relatedSpecies	[Species:2671781] Human herpesvirus 8
reviewStatus	[ReviewStatus:9821380] one star
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9980794] R-HSA-9980770.1
structureModified	[InstanceEdit:9991595] Stephan, Ralf, 2026-06-05
summation	[Summation:9980777] HHV8 pre-ORF17 dimerizes inside the procapsid to initiate th...
(hasEvent)	[Pathway:9985636] HHV8 Virion Assembly and Egress [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9980774] pre-ORF17 moves to nucleus [Homo sapiens] [Reaction:9986437] ORF17 auto-cleaves [Homo sapiens]
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No pathways have been reviewed or authored by pre-ORF17 forms dimer inside procapsid (9980770)