Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person ORF74 is sulfated

Class:IdReaction:9980420
_displayNameORF74 is sulfated
_doReleaseFALSE
_timestamp2026-03-26 19:13:59
authored[InstanceEdit:9980403] Stephan, Ralf, 2026-01-28
catalystActivity[CatalystActivity:9980415] protein-tyrosine sulfotransferase activity of Unknown protein-tyrosine sulfotransferase [Golgi membrane]
compartment[Compartment:20699] Golgi membrane
created[InstanceEdit:9980424] Stephan, Ralf, 2026-01-28
crossReference[DatabaseIdentifier:9980414] RHEA:16802
disease[Disease:3134794] viral infectious disease
goBiologicalProcess[GO_BiologicalProcess:18677] peptidyl-tyrosine sulfation
input[EntityWithAccessionedSequence:9980408] GlcNAc-N18,N22,N31,N202-ORF74 [Golgi membrane] [Human herpesvirus 8]
[SimpleEntity:741440] PAPS [Golgi lumen]
internalReviewed[InstanceEdit:9985769] Orlic-Milacic, Marija, 2026-03-26
isChimericFALSE
literatureReference[LiteratureReference:9980421] Sulfotyrosines of the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promote tumorigenesis through autocrine activation
modified[InstanceEdit:9983303] Stephan, Ralf, 2026-02-21
[InstanceEdit:9985311] Stephan, Ralf, 2026-03-18
[InstanceEdit:9985778] Stephan, Ralf, 2026-03-26
nameORF74 is sulfated
output[EntityWithAccessionedSequence:9980419] S-GlcNAc-N18,N22,N31,N202-ORF74 [Golgi membrane] [Human herpesvirus 8]
[SimpleEntity:425969] H+ [Golgi lumen]
[SimpleEntity:742343] PAP [Golgi lumen]
precedingEvent
relatedSpecies[Species:2671781] Human herpesvirus 8
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9980427] R-HSA-9980420.1
summation[Summation:9980417] An unknown Protein-tyrosine sulfotransferase sulfates HHV8 G...
(hasEvent)[Pathway:9976070] Maturation/Activation of Late HHV8 Lytic Proteins [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9980455] ORF74 moves to plasma membrane [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by ORF74 is sulfated (9980420)