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Details on Person Pharmacological activation of Notch by a recombinant ligand ...
| Class:Id | Summation:9980213 |
|---|---|
| _displayName | Pharmacological activation of Notch by a recombinant ligand ... |
| _timestamp | 2026-01-26 13:44:17 |
| created | [InstanceEdit:9980212] Orlic-Milacic, Marija, 2026-01-26 |
| text | Pharmacological activation of Notch by a recombinant ligand (Jag1) induces the phosphorylation of STAT3-Ser727. This reaction happens in the absence of detectable STAT3-Tyr705 phosphorylation (Baseline or Dll4-activated) (Androutsellis-Theotokis et al. 2006). The reaction depends on gamma secretase and mTOR activities (Androutsellis-Theotokis et al. 2006). Model cell system used was E13.5 cortical embryonic mouse CNS stem cells and recombinant Notch ligands mouse Dll4 (1389-D4) from R&D and mouse Jag1 (599-JG) from R&D (Androutsellis-Theotokis et al. 2006). |
| (summation) | [BlackBoxEvent:9980211] Notch activation positively regulates Stat3 phosphorylation on S727 [Mus musculus] |
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No pathways have been reviewed or authored by Pharmacological activation of Notch by a recombinant ligand ... (9980213)
