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Details on Person Orlic-Milacic, Marija, 2026-01-24
| Class:Id | InstanceEdit:9980035 |
| _displayName | Orlic-Milacic, Marija, 2026-01-24 |
| _timestamp | 2026-01-24 01:16:30 |
| author | [Person:1169272] Orlic-Milacic, Marija |
| dateTime | 2026-01-24 01:16:28 |
| (modified) | [Pathway:5685938] HDR through Single Strand Annealing (SSA) [Homo sapiens] [PathwayDiagram:5685945] Diagram of HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Defective homologous recombination repair (HRR) due to BRCA1 loss-of-function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function, Impaired BRCA2 binding to SEM1 (DSS1), Impaired BRCA2 binding to RAD51, Impaired BRCA2 binding to PALB2, and Impaired BRCA2 translocation to the nucleus [Summation:5686650] A DNA ligase, most likely LIG1 (DNA ligase I), ligates singl... [Reaction:5686657] ERCC1:XPF cleaves flaps generated by SSA [Homo sapiens] [CatalystActivity:5686658] DNA endonuclease activity of ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [BlackBoxEvent:5686663] Completion of SSA [Homo sapiens] |
| (structureModified) | [Pathway:5685938] HDR through Single Strand Annealing (SSA) [Homo sapiens] [Reaction:5686657] ERCC1:XPF cleaves flaps generated by SSA [Homo sapiens] [BlackBoxEvent:5686663] Completion of SSA [Homo sapiens] |
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No pathways have been reviewed or authored by Orlic-Milacic, Marija, 2026-01-24 (9980035)